公开(公告)号：US20240315984A1

公开(公告)日：2024-09-26

申请号：US18612755

申请日：2024-03-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Bhanu Prasanth Koppolu ,  Philip David Dorgan ,  Rhiannon Johnson ,  Steven L. Kangas ,  Nivedita Swetha Ramkumar ,  Matthew R. Dreher

IPC: A61K9/51 ,  A61K45/06

CPC classification number: A61K9/5153 ,  A61K9/5123 ,  A61K45/06

Abstract: The present disclosure pertains to biodegradable polymeric microspheres that comprise a biodegradable polymer and an immunotherapeutic agent selected from an inhibitor of poly ADP ribose polymerase enzyme (PARP inhibitor) and/or a Toll-like receptor (TLR) agonist wherein (a) 50% of a total amount of the immunotherapeutic agent in the biodegradable polymeric microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; (b) between 1 mg and 100 mg of immunotherapeutic agent per 1 g dry weight of microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; or (c) both (a) and (b). Other aspects of the present disclosure pertain to methods of using such microparticles and kits that contain such microparticles.