公开(公告)号：US20230149118A1

公开(公告)日：2023-05-18

申请号：US17988114

申请日：2022-11-16

Applicant: Boston Scientific Scimed, Inc.

Inventor： Patrick A. Haverkost ,  Bhanu Prasanth Koppolu ,  Joel N. Groff ,  Kyle Alan Trepanier

IPC: A61B90/00

CPC classification number: A61B90/39 ,  A61B2090/3987

Abstract: Fluid delivery devices, systems, and methods disclosed herein may include a cannula that may include a shaft comprising a proximal end, a distal end, and a lumen. A plurality of radial apertures may be disposed along a delivery portion of the shaft. Each radial aperture may be in fluid communication with the lumen. At least one echogenic marker may be disposed along the shaft within or adjacent to the delivery portion. A body may be disposed within the distal end of the shaft.

公开(公告)号：US20240315984A1

公开(公告)日：2024-09-26

申请号：US18612755

申请日：2024-03-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Bhanu Prasanth Koppolu ,  Philip David Dorgan ,  Rhiannon Johnson ,  Steven L. Kangas ,  Nivedita Swetha Ramkumar ,  Matthew R. Dreher

IPC: A61K9/51 ,  A61K45/06

CPC classification number: A61K9/5153 ,  A61K9/5123 ,  A61K45/06

Abstract: The present disclosure pertains to biodegradable polymeric microspheres that comprise a biodegradable polymer and an immunotherapeutic agent selected from an inhibitor of poly ADP ribose polymerase enzyme (PARP inhibitor) and/or a Toll-like receptor (TLR) agonist wherein (a) 50% of a total amount of the immunotherapeutic agent in the biodegradable polymeric microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; (b) between 1 mg and 100 mg of immunotherapeutic agent per 1 g dry weight of microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; or (c) both (a) and (b). Other aspects of the present disclosure pertain to methods of using such microparticles and kits that contain such microparticles.

公开(公告)号：US20220313603A1

公开(公告)日：2022-10-06

申请号：US17713596

申请日：2022-04-05

Applicant: Boston Scientific Scimed Inc.

Inventor： Viktoria Molnar ,  Carolina Villarreal ,  Bhanu Prasanth Koppolu ,  Nivedita Swetha Ramkumar ,  Philip David Dorgan

IPC: A61K9/06 ,  A61K47/36 ,  A61K47/42 ,  A61K47/02

Abstract: The present disclosure pertains to therapeutic hydrogels that comprise an anionic polysaccharide crosslinked by a branched polyamine, wherein the branched polyamine comprises at least two primary amine groups, more typically at least three primary amine groups. The present disclosure also pertains to medical compositions that comprise such therapeutic hydrogels and to methods of medical treatment in which such therapeutic hydrogels are delivered to a patient in need of medical treatment.