公开(公告)号：US20250099751A1

公开(公告)日：2025-03-27

申请号：US18893371

申请日：2024-09-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Brian L. Schmidt ,  Devon N. Arnholt ,  Michael J. Lyden ,  Michael J. Kane ,  Tucker James Nelson

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/08 ,  A61N1/375

Abstract: Embodiments herein relate to implantable systems and methods for treatment of pancreatic cancer. In an embodiment, a method of treating pancreatic cancer is included, the method including inserting an electrical stimulation lead through the inferior vena cava, a hepatic vein, and into the portal vein via a transjugular intrahepatic portosystem shunt (TIPS). The method can further include inserting the electrical stimulation lead into at least one of the superior mesenteric vein and the splenic vein. The method can further include positioning electrodes on the lead within at least one of the superior mesenteric vein and the splenic vein and delivering one or more electric fields through the electrodes to a treatment zone including at least a portion of the pancreas. The electric fields can be at frequencies and a field strength effective to prevent and/or disrupt cellular mitosis in a cell.

公开(公告)号：US20250058104A1

公开(公告)日：2025-02-20

申请号：US18799398

申请日：2024-08-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Brian L. Schmidt ,  Devon N. Arnholt ,  Michael J. Lyden ,  Michael J. Kane ,  Tucker James Nelson

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375

Abstract: Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment is included having a plurality of implantable stimulation leads, a plurality of electric field therapy electrodes, a therapy output circuit, and control circuitry. The therapy output circuit can generate an electrical current for the plurality of electric field therapy electrodes to create one or more electric fields that are effective to prevent and/or disrupt cellular mitosis in a cell. The control circuitry can be configured to cause the electrical current to be distributed asymmetrically between working electrodes and counter electrodes amongst the plurality of electric field therapy electrodes. At least some of the plurality of electric field therapy electrodes are disposed on the plurality of implantable stimulation leads and in electrical communication with the therapy output circuit. Other embodiments are also included herein.

公开(公告)号：US20210072208A1

公开(公告)日：2021-03-11

申请号：US17012642

申请日：2020-09-04

Applicant: Boston Scientific Scimed, Inc.

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Raia Colette Finc ,  Michael J. Lyden ,  John M. Darst ,  Michael Mathias Freking

IPC: G01N33/00 ,  G01N27/70 ,  G01N27/447

Abstract: Embodiments herein relate to breath analysis system. In an embodiment, a gas measurement device is included having a housing defining an interior volume. The housing can include a fluid ingress port, a fluid egress port, a bottom wall, and a circuit board disposed within the interior volume. The circuit board can include a first side and a second side, where the first side of the circuit board faces inward toward the interior volume. The circuit board can include a plurality of gas sensors disposed on the first side of the circuit board and a plurality of conductive pads disposed on the second side of the circuit board, wherein a plurality of electrical contacts contact the conductive pads when the circuit board is seated within the housing. Other embodiments are also included herein.

公开(公告)号：US20250073462A1

公开(公告)日：2025-03-06

申请号：US18819328

申请日：2024-08-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Brian L. Schmidt ,  Devon N. Arnholt ,  Michael J. Lyden ,  Michael J. Kane ,  Tucker James Nelson

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/08

Abstract: Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment is included having a therapy output circuit configured to generate an electrical current for a plurality of electric field therapy electrodes to create one or more electric fields and control circuitry that causes the therapy output circuit to generate the one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz within a bodily tissue. The control circuitry can be configured to select between operating in a first mode or a second mode of generating the electrical current for the electric field therapy electrodes based on a minimum electrical field strength threshold, wherein the first mode includes modulating amplitude of the electrical current and the second mode includes duty cycling of the electrical current. Other embodiments are also included herein.