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公开(公告)号:US07989455B2
公开(公告)日:2011-08-02
申请号:US11640476
申请日:2006-12-14
申请人: Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
发明人: Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
IPC分类号: A61K31/06 , A61K31/497 , C07D401/06 , C07D401/08
CPC分类号: C07D213/75 , C07D261/14 , C07D401/12 , C07D401/14 , C07D413/12
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US08445495B2
公开(公告)日:2013-05-21
申请号:US12483093
申请日:2009-06-11
申请人: Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
发明人: Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
IPC分类号: A61K31/497
CPC分类号: C07D213/75 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US07825120B2
公开(公告)日:2010-11-02
申请号:US11639398
申请日:2006-12-13
申请人: Bradley P. Morgan , Alex Muci , Erica A. Kraynack , Todd Tochimoto , Pu-Ping Lu , David J. Morgans, Jr.
发明人: Bradley P. Morgan , Alex Muci , Erica A. Kraynack , Todd Tochimoto , Pu-Ping Lu , David J. Morgans, Jr.
IPC分类号: A61K31/497 , C07D241/04 , C07D295/00
CPC分类号: C07D401/12 , C07D213/75 , C07D239/42 , C07D261/14 , C07D403/12 , C07D413/12
摘要: Certain substituted ((piperazin-1-ylmethyl)benzyl)urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and may be useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的((哌嗪-1-基甲基)苄基)脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20100029680A1
公开(公告)日:2010-02-04
申请号:US12483093
申请日:2009-06-11
申请人: Bradley P. Morgan , David J. Morgans, JR. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
发明人: Bradley P. Morgan , David J. Morgans, JR. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
IPC分类号: A61K31/496 , A61P9/00
CPC分类号: C07D213/75 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US07718657B2
公开(公告)日:2010-05-18
申请号:US11639390
申请日:2006-12-13
IPC分类号: A61K31/497 , C07D241/04 , C07D295/00
CPC分类号: C07D413/12 , C07D213/75 , C07D295/13 , C07D295/145 , C07D401/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US08410108B2
公开(公告)日:2013-04-02
申请号:US12772872
申请日:2010-05-03
IPC分类号: A61K31/496 , C07D241/04 , C07D401/02
CPC分类号: C07D413/12 , C07D213/75 , C07D295/13 , C07D295/145 , C07D401/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20100210634A1
公开(公告)日:2010-08-19
申请号:US12772872
申请日:2010-05-03
IPC分类号: A61K31/541 , C07D401/12 , A61K31/496 , C07D413/14 , A61K31/4725 , C07D471/04 , C07D417/14 , A61K31/5377 , A61P9/04
CPC分类号: C07D413/12 , C07D213/75 , C07D295/13 , C07D295/145 , C07D401/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US07538223B2
公开(公告)日:2009-05-26
申请号:US11498986
申请日:2006-08-04
申请人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
发明人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号: C07D211/68 , C07D401/00 , C07D459/00
CPC分类号: C07D417/12 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US07910743B2
公开(公告)日:2011-03-22
申请号:US12469603
申请日:2009-05-20
申请人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
发明人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号: C07D211/68 , C07D401/04 , C07D401/14
CPC分类号: C07D417/12 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US20090324511A1
公开(公告)日:2009-12-31
申请号:US12469603
申请日:2009-05-20
申请人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, JR.
发明人: Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, JR.
IPC分类号: A61K9/12 , A61K31/541 , A61K31/4439 , A61K31/41 , A61K31/40 , C07D417/12 , C07D285/10 , C07D207/12
CPC分类号: C07D417/12 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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