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公开(公告)号:US09938236B2
公开(公告)日:2018-04-10
申请号:US14759385
申请日:2013-12-27
发明人: Xiaodong Xu , Ju-Tao Guo , Tong Xiao , Yanming Du , Timothy Block , Simon David Peter Baugh , Hong Ye
IPC分类号: C07C311/16 , C07D213/75 , C07D213/76 , C07D309/04 , C07D215/38 , C07D215/42 , C07D217/24 , C07D319/18 , C07D231/40 , C07D231/42 , C07D239/26 , C07D261/14 , C07D263/48 , C07D263/50 , C07D203/26 , C07D263/58 , C07D205/04 , C07D277/46 , C07D277/52 , C07D211/96 , C07D295/26 , C07D295/30 , C07D213/40 , C07D305/08 , C07C309/89 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/48 , C07C233/66 , C07C317/14 , C07D295/32 , C07D319/16
CPC分类号: C07C311/16 , C07B2200/07 , C07C233/66 , C07C309/89 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/48 , C07C317/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D203/26 , C07D205/04 , C07D211/96 , C07D213/40 , C07D213/75 , C07D213/76 , C07D215/38 , C07D215/42 , C07D217/24 , C07D231/40 , C07D231/42 , C07D239/26 , C07D261/14 , C07D263/48 , C07D263/50 , C07D263/58 , C07D277/46 , C07D277/52 , C07D295/26 , C07D295/30 , C07D295/32 , C07D305/08 , C07D309/04 , C07D319/16 , C07D319/18
摘要: The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
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公开(公告)号:US20180072682A1
公开(公告)日:2018-03-15
申请号:US15557762
申请日:2016-03-18
发明人: KAREN ANNETTE DUGGAN
IPC分类号: C07D233/78 , C07C215/54 , C07D207/26 , C07D207/38 , C07D233/96 , C07D261/14 , C07D263/38 , C07C239/20 , C07D263/44 , C07D209/48 , C07C59/54 , C07C39/12
CPC分类号: C07D233/78 , C07C39/12 , C07C39/15 , C07C47/575 , C07C59/52 , C07C59/54 , C07C215/48 , C07C215/54 , C07C239/20 , C07D207/26 , C07D207/267 , C07D207/36 , C07D207/38 , C07D207/408 , C07D207/448 , C07D209/48 , C07D233/96 , C07D261/14 , C07D263/38 , C07D263/44
摘要: The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.
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公开(公告)号:US09890117B2
公开(公告)日:2018-02-13
申请号:US15187163
申请日:2016-06-20
IPC分类号: C07C311/21 , C07C311/16 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/85 , C07D217/04 , C07D207/16 , C07C317/44 , C07C323/49 , C07C323/42 , C07C257/18 , C07C255/60 , C07D295/26 , C07D305/06 , C07C311/29 , C07D213/76 , C07D213/80 , C07D223/04 , C07D237/20 , C07D239/42 , C07D261/14 , C07D271/113 , C07D277/46 , C07D403/12 , C07D413/12 , C07D417/12 , C07D311/16 , C07C311/46 , C07C317/40 , C07C323/62 , C07C311/47 , C07C317/22 , C07C317/34 , C07C323/20 , C07C235/60
CPC分类号: C07C311/21 , C07B2200/07 , C07C235/60 , C07C255/60 , C07C257/18 , C07C311/16 , C07C311/29 , C07C311/46 , C07C311/47 , C07C317/22 , C07C317/34 , C07C317/40 , C07C317/44 , C07C317/48 , C07C323/20 , C07C323/42 , C07C323/49 , C07C323/62 , C07C2601/02 , C07D207/16 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D217/04 , C07D223/04 , C07D237/20 , C07D239/42 , C07D261/14 , C07D271/113 , C07D277/46 , C07D295/26 , C07D305/06 , C07D311/16 , C07D403/12 , C07D413/12 , C07D417/12
摘要: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
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公开(公告)号:US09751885B2
公开(公告)日:2017-09-05
申请号:US14435085
申请日:2013-10-11
发明人: Naoki Tomita , Daisuke Tomita , Yusuke Tominari , Shinichi Imamura , Shinji Morimoto , Takuto Kojima , Masashi Toyofuku , Yasushi Hattori , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号: C07D487/04 , C07C255/58 , C07C255/60 , C07D231/40 , C07C317/40 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , A61K45/06 , C07D309/14 , C07D319/18 , C07D413/12 , C07D241/12 , C07D417/12 , C07D261/14 , C07D207/12 , C07D285/135 , C07D211/58 , C07D295/135 , C07D213/40 , C07D207/46 , C07D213/36 , C07D223/12 , C07D231/38 , C07D241/18 , C07D265/36 , C07D277/38 , C07D333/20 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号: C07D487/04 , A61K45/06 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , C07C255/58 , C07C255/60 , C07C317/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/46 , C07D211/58 , C07D213/36 , C07D213/40 , C07D223/12 , C07D231/38 , C07D231/40 , C07D241/12 , C07D241/18 , C07D261/14 , C07D265/36 , C07D277/38 , C07D285/135 , C07D295/135 , C07D309/14 , C07D319/18 , C07D333/20 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04
摘要: The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.
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公开(公告)号:US09751832B2
公开(公告)日:2017-09-05
申请号:US14907321
申请日:2014-07-30
申请人: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人: Eduardo M. Sotomayor , Joel A. Bergman , Alan P. Kozikowski , Alejandro V. Villagra , Karrune V. Woan
IPC分类号: C07C275/34 , C07D213/75 , C07D231/56 , C07D233/26 , C07D233/74 , C07D233/78 , C07D239/42 , C07D261/14 , C07D209/14 , C07D295/13 , C07C275/28 , C07C275/40 , A61K31/17 , A61K31/185 , A61K31/4045 , A61K31/416 , A61K31/42 , A61K31/437 , A61K31/44 , A61K31/505 , A61K45/06
CPC分类号: C07C275/34 , A61K31/17 , A61K31/185 , A61K31/4045 , A61K31/416 , A61K31/42 , A61K31/437 , A61K31/44 , A61K31/505 , A61K45/06 , C07C275/28 , C07C275/40 , C07D209/14 , C07D213/75 , C07D231/56 , C07D233/26 , C07D233/74 , C07D233/78 , C07D239/42 , C07D261/14 , C07D295/13
摘要: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Specifically, the disclosed subject matter relates to compounds having activity as selective HDAC6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds. In still further aspects, the disclosed subject matter relates to methods for treating oncological disorders in a patient. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
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6.
公开(公告)号:US20170190709A1
公开(公告)日:2017-07-06
申请号:US15382002
申请日:2016-12-16
申请人: DREXEL UNIVERSITY
IPC分类号: C07D487/04 , A61K31/425 , A61K45/06 , C07D261/14 , A61K31/42 , A61K31/53 , A61K31/4709 , C07D417/12 , A61K31/4439 , A61K31/427 , C07D401/04 , A61K31/635 , C07D275/03 , C07D413/14
CPC分类号: C07D487/04 , A61K31/341 , A61K31/381 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/427 , A61K31/4406 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/53 , A61K31/5365 , A61K31/635 , A61K45/06 , C07D261/14 , C07D275/03 , C07D401/04 , C07D413/14 , C07D417/12 , A61K2300/00
摘要: The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
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公开(公告)号:US20170165241A1
公开(公告)日:2017-06-15
申请号:US15359330
申请日:2016-11-22
申请人: CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
发明人: Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号: A61K31/4365 , A61K31/519
CPC分类号: C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号:US20170158628A1
公开(公告)日:2017-06-08
申请号:US15435814
申请日:2017-02-17
发明人: ANDREW HARVEY , THOMAS AVERY , DHARAM PAUL , JUSTIN RIPPER , BELINDA HUFF , RAJINDER SINGH , LAURENT SCHAEFFER , CHRISTOPHE JOSEPH , CHRISTOPHE MORICE , BRUNO GIETHLEN
IPC分类号: C07C311/37 , C07C311/30 , C07D261/14 , C07C217/82 , C07D213/74 , C07D295/135
CPC分类号: C07C311/37 , C07C211/53 , C07C217/82 , C07C303/36 , C07C307/10 , C07C311/08 , C07C311/30 , C07C311/39 , C07C311/48 , C07C311/49 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/50 , C07D213/74 , C07D231/38 , C07D233/72 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D261/14 , C07D277/42 , C07D295/135 , C07D305/08 , C07F9/58
摘要: The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.
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公开(公告)号:US09643925B2
公开(公告)日:2017-05-09
申请号:US14837201
申请日:2015-08-27
发明人: Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号: C07D213/75 , C07D417/00 , C07D417/10 , C07D417/12 , C07D513/04 , C07D401/10 , C07D401/12 , C07D271/113 , C07D487/04 , C07D295/26 , C07D491/04 , C07D261/14 , C07D211/56 , C07D239/42 , C07D263/48
CPC分类号: C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US09624182B2
公开(公告)日:2017-04-18
申请号:US14755383
申请日:2015-06-30
发明人: Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号: C07D417/12 , C07D413/06 , C07D413/12 , C07D495/04 , C07D261/08 , C07D261/14 , A61K31/519 , A61K31/4725 , A61K31/4439 , A61K31/427 , A61K31/4709 , C07D261/18 , C07D405/12 , A61K31/42 , A61K31/422
CPC分类号: C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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