公开(公告)号：US20220380815A1

公开(公告)日：2022-12-01

申请号：US17830229

申请日：2022-06-01

Applicant: Braskem S.A.

Inventor： Felipe GALZERANI ,  Bianca Bassetto BISSONI ,  Karine JAILLARDON ,  Dominique LOUIS

IPC: C12P7/40 ,  C12N15/52 ,  C12N1/18 ,  C12N15/81

Abstract: The present disclosure provides recombinant microorganisms and methods for producing malonate semialdehyde and/or related products, such as ketones, alcohols, organic acids, esters, alkenes, amino acids, and combinations thereof including 3-hydroxypropionic acid, acrylic acid, propionic acid, 1-propanol, acetone, 2-propanol, butanone, 1-butanol, 2-butanol, methyl propionate, 1,3-propanediol, isoamyl alcohol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, lactic acid, adipic acid, glutamic acid, itaconic acid, ethyl acetate, isopropyl acetate, acetic acid, butyric acid, caproic acid, citric acid, methacrylic acid, succinic acid, propylene, butadiene, ethanol, isoprenol, leucine, isoleucine, glutamine, glycine, and isoprene, from β-alanine. The recombinant microorganism expresses an asparate 1-decarboxylase that catalyzes the production of malonate semialdehyde from β-alanine.