公开(公告)号：US20120164697A1

公开(公告)日：2012-06-28

申请号：US13287900

申请日：2011-11-02

申请人： Brian J. BRAZEAU ,  Mervyn L. DE SOUZA ,  Steven J. GORT ,  Paula M. HICKS ,  Sherry R. KOLLMANN ,  Jose M. LAPLAZA ,  Sara C. MCFARLAN ,  Fernando A. SANCHEZ-RIERA ,  Christopher SOLHEID

发明人： Brian J. BRAZEAU ,  Mervyn L. DE SOUZA ,  Steven J. GORT ,  Paula M. HICKS ,  Sherry R. KOLLMANN ,  Jose M. LAPLAZA ,  Sara C. MCFARLAN ,  Fernando A. SANCHEZ-RIERA ,  Christopher SOLHEID

IPC分类号： C12P13/04

CPC分类号： C12N9/1096 ,  C12N9/90 ,  C12P17/10

摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

摘要翻译： 使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。 这些多肽和生物合成途径也可用于生产在特定的莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。