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公开(公告)号：US08524900B2
公开(公告)日：2013-09-03
申请号：US13309488
申请日：2011-12-01
申请人： Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5025 , A61K31/4353 , A61K31/4523 , A61P35/00
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US20120148531A1
公开(公告)日：2012-06-14
申请号：US13309488
申请日：2011-12-01
申请人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/5025 , A61K31/5377 , A61K38/21 , A61P35/00 , A61P35/04 , C07D487/04 , A61K31/538
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090318436A1
公开(公告)日：2009-12-24
申请号：US12287791
申请日：2008-10-14
申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/5355 , C07D487/02 , A61K31/5025 , C07D413/14 , C07D471/02 , A61K31/437 , A61K31/53 , C07D498/02 , A61K31/4355 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US20120107275A1
公开(公告)日：2012-05-03
申请号：US13323692
申请日：2011-12-12
申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/5025 , A61K31/5377 , C07D498/04 , A61K31/538 , A61K38/21 , A61P31/00 , A61P3/00 , A61P5/00 , A61P37/00 , C07D487/04 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US20090124612A1
公开(公告)日：2009-05-14
申请号：US11879034
申请日：2007-07-13
申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/5377 , C07D487/04 , C07D471/04 , A61P35/04 , A61K31/437 , A61K31/5025
CPC分类号： C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090124609A1
公开(公告)日：2009-05-14
申请号：US12009123
申请日：2008-01-15
申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/538 , C07D487/02 , A61K31/5025 , C07D413/14 , A61K31/5377 , A61P35/00 , C07D471/02 , A61K31/437 , A61K31/53 , C07D265/36
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US08088794B2
公开(公告)日：2012-01-03
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/47 , C07D453/02
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20110118252A1
公开(公告)日：2011-05-19
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20080312232A1
公开(公告)日：2008-12-18
申请号：US11412302
申请日：2006-04-26
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US08685983B2
公开(公告)日：2014-04-01
申请号：US13308310
申请日：2011-11-30
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/437 , A61K31/519 , A61K31/4184 , A61K31/501 , A61K31/4709 , A61K31/4365
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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