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公开(公告)号：US6093805A
公开(公告)日：2000-07-25
申请号：US915699
申请日：1997-08-21
CPC分类号： C07H15/18 , C07H15/256 , C07H17/04 , C07J17/005 , C07J9/00 , C07J9/005
摘要： Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
摘要翻译： 提供新的糖苷，特别是甾体和非甾体糖苷。 甾体和非甾体糖苷优选由具有有价值性质如药理学性质的糖苷配制剂制备。 糖苷由有用的糖苷配制而成，具有与它们各自的未糖基化糖苷基相同的有用性质。 糖苷以酰化和脱酰基形式提供。 酰基水解后的酰化糖苷具有增强的水溶性，如糖苷配基是乙酰氨基酚的情况所示。
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公开(公告)号：US5496806A
公开(公告)日：1996-03-05
申请号：US239373
申请日：1994-05-06
申请人： R. Erich Klemke
发明人： R. Erich Klemke
IPC分类号： C07H15/256 , C07H17/04 , C07J9/00 , C07J17/00 , A61K31/705
CPC分类号： C07J9/005 , C07H15/256 , C07H17/04 , C07J17/005 , C07J9/00 , Y10S514/885 , Y10S514/886
摘要： Novel glycosides 7-ketosteryl di-O-acyl-pyranoside and 7-.beta.-hydroxycholesteryl 2,3-dideoxy-.alpha.-D-erythro-hex-2-enopyranoside. The glycosides possess valuable pharmacological properties as a medicament. In particular, the cholesterol glycoside in vivo exhibits a selective cell-destructive activity on malignant cells which activity is substantially free of side effects on normal cells. The glycosides possess useful properties, especially pharmacological properties which are the same as the respective unglycosylated aglycon.
摘要翻译： 新型糖苷7-酮酯基二-O-酰基吡喃糖苷和7-β-羟基胆固醇2,3-二脱氧-α-D-赤型己-2-烯吡喃糖苷。 糖苷作为药物具有有价值的药理学性质。 特别地，体内胆固醇糖苷对恶性细胞具有选择性的细胞破坏活性，其活性对正常细胞基本上没有副作用。 糖苷具有有用的性质，特别是与各自的未糖基化糖苷配基相同的药理学性质。
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