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公开(公告)号:US10669323B2
公开(公告)日:2020-06-02
申请号:US15248712
申请日:2016-08-26
申请人: Brian R. Boettcher , Shari Lynn Caplan , Susan E. Cellitti , Douglas S. Daniels , Norio Hamamatsu , Bernhard Hubert Geierstanger , Stuart Licht , Andreas Loew , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari Lynn Caplan , Susan E. Cellitti , Douglas S. Daniels , Norio Hamamatsu , Bernhard Hubert Geierstanger , Stuart Licht , Andreas Loew , Stephen Craig Weldon
IPC分类号: A61K38/18 , A61K38/26 , C07K14/605 , C07K14/50
摘要: The present invention relates to the identification of dual function fusion proteins comprising fibroblast growth factor 21 (FGF21) and Exenatide, Exendin-4, or GLP-1. Also disclosed are methods for treating metabolic, cardiovascular, and endocrine conditions related to glucose and/or lipid homeostasis.
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公开(公告)号:US09023791B2
公开(公告)日:2015-05-05
申请号:US13296343
申请日:2011-11-15
申请人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Bernhard H. Geierstanger , Norio Hamamatsu , Stuart Licht , Andreas Loew , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Bernhard H. Geierstanger , Norio Hamamatsu , Stuart Licht , Andreas Loew , Stephen Craig Weldon
CPC分类号: A61K38/1825 , A61K47/593 , A61K47/60 , C07K14/50 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要: The present invention provides novel polypeptide and protein variants of fibroblast growth factor 21 (FGF21) and pharmaceutical compositions comprising FGF21 polypeptide and protein variants.
摘要翻译: 本发明提供了成纤维细胞生长因子21(FGF21)的新型多肽和蛋白质变体和包含FGF21多肽和蛋白质变体的药物组合物。
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公开(公告)号:US09266935B2
公开(公告)日:2016-02-23
申请号:US14630206
申请日:2015-02-24
申请人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
CPC分类号: A61K38/1825 , A61K38/00 , A61K45/06 , C07K14/50 , C07K2319/30
摘要: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
摘要翻译: 本发明涉及包含具有改善的药物性质的成纤维细胞生长因子21(FGF21)的多肽和蛋白质变体的融合蛋白的鉴定。 还公开了治疗FGF21相关疾病(包括代谢病症)的方法。
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公开(公告)号:US20130079500A1
公开(公告)日:2013-03-28
申请号:US13626194
申请日:2012-09-25
申请人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
IPC分类号: C07K19/00
CPC分类号: A61K38/1825 , A61K38/00 , A61K45/06 , C07K14/50 , C07K2319/30
摘要: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
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公开(公告)号:US20150166622A1
公开(公告)日:2015-06-18
申请号:US14630206
申请日:2015-02-24
申请人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
CPC分类号: A61K38/1825 , A61K38/00 , A61K45/06 , C07K14/50 , C07K2319/30
摘要: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
摘要翻译: 本发明涉及包含具有改善的药物性质的成纤维细胞生长因子21(FGF21)的多肽和蛋白质变体的融合蛋白的鉴定。 还公开了治疗FGF21相关疾病(包括代谢病症)的方法。
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公开(公告)号:US09006400B2
公开(公告)日:2015-04-14
申请号:US13626194
申请日:2012-09-25
申请人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
发明人: Brian R. Boettcher , Shari L. Caplan , Douglas S. Daniels , Norio Hamamatsu , Stuart Licht , Stephen Craig Weldon
CPC分类号: A61K38/1825 , A61K38/00 , A61K45/06 , C07K14/50 , C07K2319/30
摘要: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.
摘要翻译: 本发明涉及包含具有改善的药物性质的成纤维细胞生长因子21(FGF21)的多肽和蛋白质变体的融合蛋白的鉴定。 还公开了治疗FGF21相关疾病(包括代谢病症)的方法。
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