公开(公告)号：US20070048215A1

公开(公告)日：2007-03-01

申请号：US10575523

申请日：2004-10-18

Applicant: Brian Springthorpe ,  Gert Strandlund

Inventor： Brian Springthorpe ,  Gert Strandlund

IPC: A61K51/00 ,  C07D471/04 ,  A61K31/4745

CPC classification number: C07D471/08

Abstract: The present invention relates to a labelled ligand compound that is useful in a method of identifying, testing and/or screening of compounds modulating ion channels, in particular myocardial I?Kr# 191 channels such as those encoded by ERG, including hERG. The ligand compound is therefore of use to evaluate the affinity of preclinical compounds at the ERG potassium channel. The or salts, hydrates or solvates thereof and comprising at least one radiolabel: Formula (I).

Abstract translation: 本发明涉及标记的配体化合物，其可用于鉴定，测试和/或筛选调节离子通道的化合物，特别是心肌IκKr＃191通道（例如由ERG编码的那些，包括hERG）的化合物。 因此，配体化合物可用于评估临床前化合物在ERG钾通道的亲和力。 其盐或其盐，水合物或溶剂合物并且包含至少一种放射性标记：式（I）。

公开(公告)号：US20090099162A2

公开(公告)日：2009-04-16

申请号：US12028955

申请日：2008-02-11

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: A61K31/5383 ,  C07D295/00 ,  A61P9/00

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 4，R 41至R 46，A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常 。

公开(公告)号：US07354917B2

公开(公告)日：2008-04-08

申请号：US11570439

申请日：2005-06-13

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: C07D498/08 ,  A61K31/5386

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular a trial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 4，R 41与R A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是试验和室性心律失常。

公开(公告)号：US20080249086A1

公开(公告)日：2008-10-09

申请号：US12028955

申请日：2008-02-11

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: A61K31/5383 ,  C07D295/00 ,  A61P9/00

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 4，R 41与R A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

公开(公告)号：US20080207899A1

公开(公告)日：2008-08-28

申请号：US12029483

申请日：2008-02-12

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: C07D498/08

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

公开(公告)号：US20060166980A1

公开(公告)日：2006-07-27

申请号：US11385861

申请日：2006-03-22

Applicant: Annika Bjore ,  Magnus Bjorsne ,  David Cladingboel ,  Kurt-Jurgen Hoffmann ,  John Pavey ,  Fritiof Ponten ,  Gert Strandlund ,  Peder Svensson ,  Colin Thomson ,  Michael Wilsterman

Inventor： Annika Bjore ,  Magnus Bjorsne ,  David Cladingboel ,  Kurt-Jurgen Hoffmann ,  John Pavey ,  Fritiof Ponten ,  Gert Strandlund ,  Peder Svensson ,  Colin Thomson ,  Michael Wilsterman

IPC: C07D487/04 ,  A61K31/538

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

公开(公告)号：US07144914B2

公开(公告)日：2006-12-05

申请号：US10467043

申请日：2002-01-29

Applicant: Magnus Björsne ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilstermann

Inventor： Magnus Björsne ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilstermann

IPC: A61K31/407 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: There is provided compounds of formula (I) wherein R1 to R4, Ra to Rf, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式（I）化合物，其中R 1至R 4，R a至R f，R f， A和B具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和心室心律失常。

公开(公告)号：US07012074B2

公开(公告)日：2006-03-14

申请号：US10399663

申请日：2001-10-18

Applicant: Magnus Bjorsne ,  Kurt-Jürgen Hoffmann ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilstermann

Inventor： Magnus Bjorsne ,  Kurt-Jürgen Hoffmann ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilstermann

IPC: A01N43/58

CPC classification number: C07D487/08 ,  A61K31/495

Abstract: There is provided compounds of formula (I), wherein R1, R2 and Ra to Rb have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供了式（I）的化合物，其中R 1，R 2和R 2至R b， 具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

公开(公告)号：US06559162B2

公开(公告)日：2003-05-06

申请号：US09763892

申请日：2001-02-28

Applicant: Magnus Björsne ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson

Inventor： Magnus Björsne ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson

IPC: A61K31439

CPC classification number: C07D221/24

Abstract: Compounds of formula I, wherein R1, R2, R3 and Ra Rh are as defined in the specification. The compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular a trial and ventricular arrhythmias.

Abstract translation: 式I的化合物，其中R 1，R 2，R 3和R a Rh如说明书中所定义。 这些化合物可用于预防和治疗心律不齐，特别是试验和室性心律失常。

公开(公告)号：US06465481B1

公开(公告)日：2002-10-15

申请号：US09623707

申请日：2000-09-07

Applicant: Marianne Frantsi ,  Kurt-Jürgen Hoffmann ,  Gert Strandlund

Inventor： Marianne Frantsi ,  Kurt-Jürgen Hoffmann ,  Gert Strandlund

IPC: A61K3144

CPC classification number: C07D471/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R5a, R5b, R6, R9, X, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供了式I化合物，其中R1，R2，R3，R4，R5a，R5b，R6，R9，X，A和B具有说明书中给出的含义，其可用于预防和治疗心律失常， 特别是心房和室性心律失常。