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公开(公告)号：US20220283151A1
公开(公告)日：2022-09-08
申请号：US17653643
申请日：2022-03-04
发明人： Jonathon T. HILL
IPC分类号： G01N33/535 , C07K14/00 , G01N33/531
摘要： A system for regulating protein dimerization kinetics is provided herein. The system includes a first polypeptide comprising a first alpha helix forming amino acid sequence configured to bind a second alpha helix forming amino acid sequence linked by a first flexible linker peptide; and a second polypeptide comprising a third alpha helix forming amino acid sequence configured to bind a fourth alpha helix forming amino acid sequence linked by a second flexible linker peptide. The first alpha helix forming amino acid sequence and the third alpha helix forming amino acid sequence are configured to form a coiled coil. The second alpha helix forming amino acid sequence and the fourth alpha helix forming amino acid sequence are configured to form a coiled coil.
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公开(公告)号：US20220178923A1
公开(公告)日：2022-06-09
申请号：US17457594
申请日：2021-12-03
发明人： Jonathon T. HILL
IPC分类号： G01N33/569 , G01N33/58
摘要： The composition includes a first construct having a first portion of a protein and a first antigen-recognizing amino acid sequence; and a second construct having a second portion of the protein that catalyzes a reaction when combined with the first portion of the protein and a second antigen-recognizing amino acid sequence. The first and second synthetic constructs include a sulfhydryl group configured such that a disulfide bond is formed between the first and second synthetic constructs when the first antigen-recognizing amino acid sequence and the second antigen-recognizing amino acid sequence bind an antigen.
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