公开(公告)号：US20220196582A1

公开(公告)日：2022-06-23

申请号：US17609246

申请日：2020-05-07

申请人： BrightSpec, Inc.

发明人： Justin L. Neill ,  Matt Muckle ,  Alexander V. Mikhonin ,  Walter H. Colsman ,  Daniel W. Armstrong

IPC分类号： G01N23/2258 ,  G01N30/72

摘要： The capabilities of a gas or liquid chromatography-molecular rotational resonance (GC/LC-MRR) instrument exceed those of high-resolution mass spectrometry and nuclear magnetic resonance in terms of selectivity, resolution, and compound identification. MRR detection provides high specificity for selective gas- or liquid-phase separations, including the ability to resolve co-eluting peaks and isomeric compounds without any loss of specificity or accuracy. MRR can perform both qualitative identification and absolute quantification of analyte components separated by GC or LC without a reference standard. GC-MRR is ideal for compound-specific isotope analysis (CSIA) and can identify enantiomers and enantiomeric excess. GC-MRR measurements are especially useful for studying biosynthetic/degradation and geochemical isotopic compounds.