公开(公告)号：US20190033235A1

公开(公告)日：2019-01-31

申请号：US16021476

申请日：2018-06-28

申请人： BrightSpec, Inc.

发明人： Justin L. Neill ,  Brent HARRIS ,  Brooks Hart Pate

IPC分类号： G01N22/00

摘要： Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.

公开(公告)号：US20210302340A1

公开(公告)日：2021-09-30

申请号：US17266260

申请日：2019-08-08

申请人： Justin L. NEILL ,  Matt MUCKLE ,  Roger REYNOLDS ,  BrightSpec, Inc.

发明人： Justin L. Neill ,  Matt Muckle ,  Roger Reynolds

IPC分类号： G01N24/08 ,  G01R33/46 ,  G01R33/485 ,  A61B5/055

摘要： Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation.

公开(公告)号：US20240085286A1

公开(公告)日：2024-03-14

申请号：US18514320

申请日：2023-11-20

申请人： BrightSpec, Inc.

发明人： Voislav Blagojevic ,  Chris Thompson ,  Justin L. Neill

IPC分类号： G01N1/40 ,  G01N1/02 ,  G01N30/72 ,  G01N30/86

CPC分类号： G01N1/4022 ,  G01N1/02 ,  G01N30/7246 ,  G01N30/7253 ,  G01N30/86 ,  G01N2001/028 ,  H01J49/165

摘要： Molecular rotational resonance (MRR) spectroscopy can be used to characterize neutral, gas-phase molecules with very fine spectral resolution. Typically, the analyte molecules are placed in solution, which is heated initially to evaporate the solvent, then heated more to volatilize the analyte. Unfortunately, this approach does not always work well for analytes with low volatilities or susceptibility to thermal degradation. These analytes can be volatilized instead using laser-induced acoustic desorption (LIAD), flash vaporization, or nebulization. In LIAD, the analyte is dried onto a metal foil, which is illuminated by a laser. The laser beam generates an acoustic wave in the metal foil that shakes off the analyte. In flash vaporization, a small amount of liquid analyte drips onto a very hot surface, where it vaporizes too quickly to degrade. And in nebulization, a nebulizer pumps a fine spray of analyte into a heated transfer tube, where the solvent evaporates.

公开(公告)号：US20220196582A1

公开(公告)日：2022-06-23

申请号：US17609246

申请日：2020-05-07

申请人： BrightSpec, Inc.

发明人： Justin L. Neill ,  Matt Muckle ,  Alexander V. Mikhonin ,  Walter H. Colsman ,  Daniel W. Armstrong

IPC分类号： G01N23/2258 ,  G01N30/72

摘要： The capabilities of a gas or liquid chromatography-molecular rotational resonance (GC/LC-MRR) instrument exceed those of high-resolution mass spectrometry and nuclear magnetic resonance in terms of selectivity, resolution, and compound identification. MRR detection provides high specificity for selective gas- or liquid-phase separations, including the ability to resolve co-eluting peaks and isomeric compounds without any loss of specificity or accuracy. MRR can perform both qualitative identification and absolute quantification of analyte components separated by GC or LC without a reference standard. GC-MRR is ideal for compound-specific isotope analysis (CSIA) and can identify enantiomers and enantiomeric excess. GC-MRR measurements are especially useful for studying biosynthetic/degradation and geochemical isotopic compounds.

公开(公告)号：US11029261B2

公开(公告)日：2021-06-08

申请号：US16807270

申请日：2020-03-03

申请人： BrightSpec, Inc.

发明人： Justin L. Neill ,  Brent Harris ,  Brooks Hart Pate

IPC分类号： G01N22/00 ,  G01J3/44 ,  G01J3/42 ,  G01J3/45 ,  G01N21/63 ,  G01N21/35 ,  G01J3/453 ,  G01N21/3581

摘要： Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.

公开(公告)号：US20200209170A1

公开(公告)日：2020-07-02

申请号：US16807270

申请日：2020-03-03

申请人： BrightSpec, Inc.

发明人： Justin L. Neill ,  Brent HARRIS ,  Brooks Hart Pate

IPC分类号： G01N22/00 ,  G01N21/63 ,  G01J3/453 ,  G01J3/42 ,  G01J3/44

摘要： Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.

公开(公告)号：US10107744B2

公开(公告)日：2018-10-23

申请号：US15319313

申请日：2015-06-16

申请人： University of Virginia Patent Foundation ,  BrightSpec, Inc.

发明人： Brooks Hart Pate ,  Amanda Steber ,  Brent Harris

IPC分类号： G01N21/35 ,  G01N21/3586

摘要： Apparatus and techniques for broadband Fourier transform spectroscopy can include frequency hopping spread-spectrum spectroscopy approaches. For example, an excitation source power can be spread over a specified frequency bandwidth, such as by applying a sequence of short, transform-limited pulses to a sample. Each pulse can include a specified carrier frequency, and a corresponding bandwidth of the individual pulse can be determined by a frequency domain representation when Fourier transformed. A series of short excitation pulses can be used to create an excitation sequence, such as to deliver a specified or desired amount of power to the sample, such as by having the excitation source enabled for a time comparable to a free induction decay (FID) dephasing time.