公开(公告)号：US20230272100A1

公开(公告)日：2023-08-31

申请号：US17819287

申请日：2022-08-11

申请人： Bristol-Myers Squibb Company

发明人： Zhehong CAI ,  Indrani CHAKRABORTY ,  Marie-Michelle Navarro GARCIA ,  Thomas D. KEMPE ,  Alan J. KORMAN ,  Alexander T. KOZHICH ,  Hadia LEMAR ,  Mark MAURER ,  Christina Maria MILBURN ,  Michael QUIGLEY ,  Xiang SHAO ,  Mohan SRINIVASAN ,  Kent THUDIUM ,  Susan Chien-Szu WONG ,  Jochem GOKEMEIJER ,  Xi-Tao WANG ,  Han CHANG ,  Patrick GUIRNALDA

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  G01N33/574

CPC分类号： C07K16/2878 ,  C07K16/30 ,  C07K16/3069 ,  C07K16/3038 ,  C07K16/3023 ,  A61P35/00 ,  A61K39/3955 ,  G01N33/574 ,  C07K2317/76 ,  C07K2317/565 ,  C07K2317/34 ,  C07K2317/21 ,  A61K2039/505

摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US20180237534A1

公开(公告)日：2018-08-23

申请号：US15577375

申请日：2016-05-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zhehong CAI ,  Indrani CHAKRABORTY ,  Marie-Michelle Navarro GARCIA ,  Thomas D. KEMPE ,  Alan J. KORMAN ,  Alexander T. KOZHICH ,  Hadia LEMAR ,  Mark MAURER ,  Christina Maria MILBURN ,  Michael QUIGLEY ,  Maria RODRIGUEZ ,  Xiang SHAO ,  Mohan SRINIVASAN ,  Brenda L. STEVENS ,  Kent THUDIUM ,  Susan Chien-Szu WONG ,  Jochem GOKEMEIJER ,  Xi-Tao WANG ,  Han CHANG ,  Christine HUANG ,  Maria JURE-KUNKEL ,  Zheng YANG ,  Yan FENG ,  Patrick GUIRNALDA ,  Nils LONBERG ,  Bryan C. BARNHART ,  Aaron P. YAMNIUK ,  Karla A. HENNING ,  Michelle Minhua HAN ,  Ming LEI ,  Liang SCHWEIZER ,  Sandra V. HATCHER ,  Arvind RAJPAL ,  Praveen AANUR ,  Mark J. SELBY

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  G01N33/574 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574 ,  G01N2333/70514

摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US20170306035A1

公开(公告)日：2017-10-26

申请号：US15474731

申请日：2017-03-30

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zhehong CAI ,  Indrani CHAKRABORTY ,  Marie-Michelle Navarro GARCIA ,  Thomas D. KEMPE ,  Alan J. KORMAN ,  Alexander T. KOZHICH ,  Hadia LEMAR ,  Mark MAURER ,  Christina Maria MILBURN ,  Michael QUIGLEY ,  Xiang SHAO ,  Mohan SRINIVASAN ,  Kent THUDIUM ,  Susan Chien-Szu WONG ,  Jochem GOKEMEIJER ,  Xi-Tao WANG ,  Han CHANG ,  Patrick GUIRNALDA

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574 ,  G01N2333/70514

摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US20160347849A1

公开(公告)日：2016-12-01

申请号：US15166114

申请日：2016-05-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zhehong CAI ,  Indrani CHAKRABORTY ,  Marie-Michelle Navarro GARCIA ,  Thomas D. KEMPE ,  Alan J. KORMAN ,  Alexander T. KOZHICH ,  Hadia LEMAR ,  Mark MAURER ,  Christina Maria MILBURN ,  Michael QUIGLEY ,  Maria RODRIGUEZ ,  Xiang SHAO ,  Mohan SRINIVASAN ,  Brenda L. STEVENS ,  Kent THUDIUM ,  Susan Chien-Szu WONG ,  Jochem GOKEMEIJER ,  Xi-Tao WANG ,  Han CHANG ,  Christine HUANG ,  Maria JURE-KUNKEL ,  Zheng YANG ,  Yan FENG ,  Patrick GUIRNALDA ,  Nils LONBERG ,  Bryan C. BARNHART ,  Aaron P. YAMNIUK ,  Karla A. HENNING ,  Michelle Minhua HAN ,  Ming LEI ,  Liang SCHWEIZER ,  Sandra V. HATCHER ,  Arvind RAJPAL ,  Praveen AANUR ,  Mark J. SELBY

IPC分类号： C07K16/28 ,  C07K16/30

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574

摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

摘要翻译： 本文提供了结合OX40的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如在癌症的治疗中。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。