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公开(公告)号：US20180164321A1
公开(公告)日：2018-06-14
申请号：US15578874
申请日：2016-06-02
发明人： Xi-Tao WANG , Olufemi A. ADELAKUN , Anne C. LEWIN , Alan J. KORMAN , Mark J. SELBY , Changyu WANG , Haichun HUANG , Karla A. HENNING , Nils LONBERG , Mohan SRINIVASAN , Michelle Minhua HAN , Guodong CHEN , Richard Y. HUANG , Indrani CHAKRABORTY , Susan Chien-Szu WONG , Huiming LI
IPC分类号： G01N33/574 , C07K16/28
摘要： Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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2.发明申请公开(公告)号：US20180002432A1
公开(公告)日：2018-01-04
申请号：US15646558
申请日：2017-07-11
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla HENNING , Michelle Minhua HAN , Guodong CHEN , Richard HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan WONG , Huiming LI
IPC分类号： C07K16/28 , G01N33/574 , A61K47/68 , G01N33/68 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6863 , G01N33/6872 , G01N2333/70578 , G01N2333/7151
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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3.发明申请公开(公告)号：US20160145342A1
公开(公告)日：2016-05-26
申请号：US14949424
申请日：2015-11-23
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla HENNING , Michelle Minhua HAN , Guodong CHEN , Richard HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan WONG , Huiming LI
IPC分类号： C07K16/28 , G01N33/574 , A61K39/395
CPC分类号： C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872 , G01N2333/70578
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US20230272100A1
公开(公告)日：2023-08-31
申请号：US17819287
申请日：2022-08-11
发明人： Zhehong CAI , Indrani CHAKRABORTY , Marie-Michelle Navarro GARCIA , Thomas D. KEMPE , Alan J. KORMAN , Alexander T. KOZHICH , Hadia LEMAR , Mark MAURER , Christina Maria MILBURN , Michael QUIGLEY , Xiang SHAO , Mohan SRINIVASAN , Kent THUDIUM , Susan Chien-Szu WONG , Jochem GOKEMEIJER , Xi-Tao WANG , Han CHANG , Patrick GUIRNALDA
IPC分类号： C07K16/28 , C07K16/30 , A61P35/00 , A61K39/395 , G01N33/574
CPC分类号： C07K16/2878 , C07K16/30 , C07K16/3069 , C07K16/3038 , C07K16/3023 , A61P35/00 , A61K39/3955 , G01N33/574 , C07K2317/76 , C07K2317/565 , C07K2317/34 , C07K2317/21 , A61K2039/505
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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5.发明申请公开(公告)号：US20220175921A1
公开(公告)日：2022-06-09
申请号：US17531061
申请日：2021-11-19
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla A. HENNING , Michelle Minhua HAN , Guodong CHEN , Richard Y. HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan Chien-Szu WONG , Huiming LI , Bryan C. BARNHART , Aaron P. YAMNIUK , Ming LEI , Liang SCHWEIZER , Sandra V. HATCHER , Arvind RAJPAL
IPC分类号： A61K39/395 , C07K16/28 , G01N33/574 , G01N33/68
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US20180237534A1
公开(公告)日：2018-08-23
申请号：US15577375
申请日：2016-05-26
发明人： Zhehong CAI , Indrani CHAKRABORTY , Marie-Michelle Navarro GARCIA , Thomas D. KEMPE , Alan J. KORMAN , Alexander T. KOZHICH , Hadia LEMAR , Mark MAURER , Christina Maria MILBURN , Michael QUIGLEY , Maria RODRIGUEZ , Xiang SHAO , Mohan SRINIVASAN , Brenda L. STEVENS , Kent THUDIUM , Susan Chien-Szu WONG , Jochem GOKEMEIJER , Xi-Tao WANG , Han CHANG , Christine HUANG , Maria JURE-KUNKEL , Zheng YANG , Yan FENG , Patrick GUIRNALDA , Nils LONBERG , Bryan C. BARNHART , Aaron P. YAMNIUK , Karla A. HENNING , Michelle Minhua HAN , Ming LEI , Liang SCHWEIZER , Sandra V. HATCHER , Arvind RAJPAL , Praveen AANUR , Mark J. SELBY
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , G01N33/574 , A61P35/00
CPC分类号： C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574 , G01N2333/70514
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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7.发明申请ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF 有权抗葡萄球菌诱导的肿瘤坏死因子受体（GITR）的抗体及其用途公开(公告)号：US20150353637A1
公开(公告)日：2015-12-10
申请号：US14732082
申请日：2015-06-05
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla HENNING , Michelle Minhua HAN , Guodong CHEN , Richard HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan WONG , Huiming LI
IPC分类号： C07K16/28 , G01N33/68 , G01N33/574 , A61K39/395
CPC分类号： C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872 , G01N2333/70578
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
摘要翻译： 本文提供了结合糖皮质激素诱导型TNF受体（GITR）的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如在癌症的治疗中。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。
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8.发明申请公开(公告)号：US20230050665A1
公开(公告)日：2023-02-16
申请号：US17364107
申请日：2021-06-30
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla HENNING , Michelle Minhua HAN , Guodong CHEN , Richard HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan WONG , Huiming LI
IPC分类号： C07K16/28 , A61K39/395 , G01N33/68 , G01N33/574
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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9.发明申请公开(公告)号：US20180339042A1
公开(公告)日：2018-11-29
申请号：US15776591
申请日：2016-11-17
发明人： Changyu WANG , Nils LONBERG , Alan J. KORMAN , Mark J. SELBY , Mohan SRINIVASAN , Karla A. HENNING , Michelle Minhua HAN , Guodong CHEN , Richard HUANG , Indrani CHAKRABORTY , Haichun HUANG , Susan Chien-Szu WONG , Huiming LI , Bryan C. BARNHART , Aaron P. YAMNIUK , Ming LEI , Liang SCHWEIZER , Sandra V. HATCHER , Arvind RAJPAL
IPC分类号： A61K39/395 , C07K16/28 , A61P35/04 , G01N33/68 , G01N33/574
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US20170306035A1
公开(公告)日：2017-10-26
申请号：US15474731
申请日：2017-03-30
发明人： Zhehong CAI , Indrani CHAKRABORTY , Marie-Michelle Navarro GARCIA , Thomas D. KEMPE , Alan J. KORMAN , Alexander T. KOZHICH , Hadia LEMAR , Mark MAURER , Christina Maria MILBURN , Michael QUIGLEY , Xiang SHAO , Mohan SRINIVASAN , Kent THUDIUM , Susan Chien-Szu WONG , Jochem GOKEMEIJER , Xi-Tao WANG , Han CHANG , Patrick GUIRNALDA
CPC分类号： C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574 , G01N2333/70514
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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