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公开(公告)号：US20190062399A1
公开(公告)日：2019-02-28
申请号：US16042977
申请日：2018-07-23
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： C07K14/705 , C07K16/28 , A61K38/19 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US20210246188A1
公开(公告)日：2021-08-12
申请号：US17105358
申请日：2020-11-25
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： C07K14/705 , A61K38/19 , C07K16/28
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US20190092836A1
公开(公告)日：2019-03-28
申请号：US16044252
申请日：2018-07-24
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： C07K14/705 , A61K38/19 , C07K16/28 , A61K38/00 , B01D15/38
CPC分类号： C07K14/70521 , A61K38/00 , A61K38/195 , B01D15/3804 , C07K16/2818 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US10851150B2
公开(公告)日：2020-12-01
申请号：US16044252
申请日：2018-07-24
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , C07K14/705 , A61K38/19 , C07K16/28 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US20200017569A9
公开(公告)日：2020-01-16
申请号：US16044252
申请日：2018-07-24
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： C07K14/705 , A61K38/19 , C07K16/28 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US12030923B2
公开(公告)日：2024-07-09
申请号：US17105358
申请日：2020-11-25
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , A61K38/19 , C07K14/705 , C07K16/28 , A61K38/00 , B01D15/38
CPC分类号： C07K14/70521 , A61K38/195 , C07K16/2818 , A61K38/00 , B01D15/3804 , C07K2317/73 , C07K2317/76 , C07K2319/30 , B01D15/3804 , B01D15/363 , B01D15/327 , G01N30/461 , A61K38/195 , A61K2300/00
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US10941189B2
公开(公告)日：2021-03-09
申请号：US16042977
申请日：2018-07-23
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , C07K14/705 , A61K38/19 , C07K16/28 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US10808021B2
公开(公告)日：2020-10-20
申请号：US16044217
申请日：2018-07-24
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , C07K14/705 , A61K38/19 , C07K16/28 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US20190092835A1
公开(公告)日：2019-03-28
申请号：US16044217
申请日：2018-07-24
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： C07K14/705 , C07K16/28 , A61K38/19 , A61K38/00 , B01D15/38
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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