公开(公告)号：US5430194A

公开(公告)日：1995-07-04

申请号：US265207

申请日：1994-06-24

申请人： Bruce A. Barner ,  John R. Briggs ,  Jonathan J. Kurland ,  Charles G. Moyers, Jr.

发明人： Bruce A. Barner ,  John R. Briggs ,  Jonathan J. Kurland ,  Charles G. Moyers, Jr.

IPC分类号： C07C45/50 ,  C07C45/67 ,  C07C45/72 ,  C07C45/78 ,  C07C45/81

CPC分类号： C07C45/81 ,  C07C45/505 ,  C07C45/67 ,  C07C45/72 ,  C07C45/786 ,  Y02P20/582

摘要： The present invention relates to a process for producing an optically active aldehyde (first aldehyde) containing a reduced amount of the corresponding enantiomeric aldehyde (second aldehyde) which process comprises: (1) providing an initial solution containing a non-eutectic mixture of the first aldehyde and the second aldehyde, which mixture has a composition in the compositional region where only the first aldehyde crystallizes when its solubility limit in the solution is exceeded, and (2) maintaining the solution at a temperature above the eutectic temperature of the mixture and under conditions such that the solubility limit of the first aldehyde is exceeded so as to form a crystalline first aldehyde containing relatively less of the second aldehyde than was present in the initial solution.

摘要翻译： 本发明涉及一种制备含有减少量的相应对映体醛（第二醛）的光学活性醛（第一醛）的方法，该方法包括：（1）提供含有第一 醛和第二醛，该混合物在其超过溶液中的溶解度极限时只有第一醛结晶的组成区域中具有组成，和（2）将溶液保持在高于混合物的共晶温度的温度下， 使得超过第一醛的溶解度极限的条件以便形成比初始溶液中存在的含有相对较少第二醛的结晶第一醛。