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    Capsule system
    1.
    发明授权
    Capsule system 失效
    胶囊系统

    公开(公告)号：US06248354B1

    公开(公告)日：2001-06-19

    申请号：US09262623

    申请日：1999-03-04

    申请人： Bruce A. Firestone ,  Thao T. Tran

    发明人： Bruce A. Firestone ,  Thao T. Tran

    IPC分类号： A61K948

    CPC分类号： A61K9/4841 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/4858 ,  A61K31/4436 ,  A61K31/455

    摘要： A capsule system for oral delivery of an active agent having low aqueous solubility generally includes, in combination with the active agent, a vehicle for preventing initial active agent dissolution within the gastrointestinal tract and an emulsifier for promoting self-emulsification of the active agent and vehicle in the gastrointestinal tract. A capsule shell is provided for encapsulating the active agent, vehicle and emulsifier with the shell being formulated to open upon ingestion into the gastrointestinal tract and release the active agent and vehicle.

    摘要翻译： 用于口服递送具有低水溶性的活性剂的胶囊系统通常包括与活性剂组合用于防止初始活性剂溶解在胃肠道内的载体和用于促进活性剂和载体的自乳化的乳化剂 在胃肠道。 提供胶囊壳，用于包封活性剂，载体和乳化剂，其中壳被配制成在摄入胃肠道时开放并释放活性剂和载体。

    Capsule system
    2.
    发明授权
    Capsule system 失效
    胶囊系统

    公开(公告)号：US06656500B2

    公开(公告)日：2003-12-02

    申请号：US09760133

    申请日：2001-01-12

    申请人： Bruce A. Firestone ,  Thao T. Tran

    发明人： Bruce A. Firestone ,  Thao T. Tran

    IPC分类号： A61K948

    CPC分类号： A61K9/4841 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/4858 ,  A61K31/4436 ,  A61K31/455

    摘要： A capsule system for oral delivery of an active agent having low aqueous solubility generally includes, in combination with the active agent, a vehicle for preventing initial active agent dissolution within the gastrointestinal tract and an emulsifier for promoting self-emulsification of the active agent and vehicle in the gastrointestinal tract. A capsule shell is provided for encapsulating the active agent, vehicle and emulsifier with the shell being formulated to open upon ingestion into the gastrointestinal tract and release the active agent and vehicle.

    摘要翻译： 用于口服递送低水溶性活性剂的胶囊系统通常包括与活性剂组合用于防止初始活性剂溶解在胃肠道内的载体和用于促进活性剂和载体的自乳化的乳化剂 在胃肠道。 提供胶囊壳，用于包封活性剂，载体和乳化剂，其中壳被配制成在摄入胃肠道时开放并释放活性剂和载体。

    Cyclosporin compositions
    6.
    发明授权
    Cyclosporin compositions 有权
    环孢菌素组合物

    公开(公告)号：US07288520B2

    公开(公告)日：2007-10-30

    申请号：US11255821

    申请日：2005-10-19

    申请人： James N. Chang ,  Orest Olejnik ,  Bruce A. Firestone

    发明人： James N. Chang ,  Orest Olejnik ,  Bruce A. Firestone

    IPC分类号： A61K38/12

    CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/1075 ,  A61K36/00 ,  A61K47/44 ,  Y10S514/912 ,  Y10S514/975 ,  A61K2300/00

    摘要： A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

    摘要翻译： 本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的 醇或烷基酚乙氧基化物，羧酸/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基 衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚， 丙氧基化脂肪酸，基于蛋白质的surfa 硅藻土衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。

    CYCLOSPORIN COMPOSITIONS
    10.
    发明申请
    CYCLOSPORIN COMPOSITIONS 有权
    环磷酰胺组合物

    公开(公告)号：US20120270805A1

    公开(公告)日：2012-10-25

    申请号：US13536479

    申请日：2012-06-28

    申请人： JAMES N. CHANG ,  Orest Olejnik ,  Bruce A. Firestone

    发明人： JAMES N. CHANG ,  Orest Olejnik ,  Bruce A. Firestone

    IPC分类号： A61K38/13 ,  A61P27/02

    CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/107 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44

    摘要： A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

    摘要翻译： 本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的 醇或烷基酚乙氧基化物，羧酸/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基 衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚， 丙氧基化脂肪酸，基于蛋白质的surfa 硅藻土衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。