公开(公告)号：US06767555B2

公开(公告)日：2004-07-27

申请号：US10217732

申请日：2002-08-13

申请人： Michael Ambuhl ,  Barbara Lückel ,  Barbara Haberlin ,  Armin Meinzer

发明人： Michael Ambuhl ,  Barbara Lückel ,  Barbara Haberlin ,  Armin Meinzer

IPC分类号： A61K948

CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K38/13

摘要： This invention provides composition comprising a cyclosporin and a carrier medium.

摘要翻译： 本发明提供包含环孢菌素和载体介质的组合物。

公开(公告)号：US06716450B1

公开(公告)日：2004-04-06

申请号：US09859260

申请日：2001-05-17

申请人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

发明人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

IPC分类号： A61K948

CPC分类号： A61K9/5146 ,  A61K31/74 ,  A61K31/765

摘要： Nanocapsules useful for encapsulating bioactive molecules such as proteins are disclosed. These nanocapsules are comprised of branched or hyperbranched polymers and copolymers and have a core-shell structure forming a pocket volume appropriate for complexing and retaining enzymes and other bioactive molecules. The nanoencapsulated bioactive molecule is stable in extreme temperatures and pH, soluble in aqueous or organic solvents, and can be lyophilized to a dry powder for long-term storage without loss of enzyme activity.

摘要翻译： 公开了可用于包封生物活性分子如蛋白质的纳米胶囊。 这些纳米胶囊由支链或超支化聚合物和共聚物组成，并且具有形成适于络合和保留酶和其它生物活性分子的口袋体积的核 - 壳结构。 纳米封装的生物活性分子在极端温度和pH下是稳定的，可溶于水溶液或有机溶剂，并且可以冻干至干燥粉末以进行长期保存而不损失酶活性。

公开(公告)号：US06709675B1

公开(公告)日：2004-03-23

申请号：US09743248

申请日：2001-03-05

申请人： Pascal Lombardin ,  Jean-Louis Grossiord ,  Monique Seiller ,  Elie Leverd ,  Eric Goutay ,  Joël Bougaret

发明人： Pascal Lombardin ,  Jean-Louis Grossiord ,  Monique Seiller ,  Elie Leverd ,  Eric Goutay ,  Joël Bougaret

IPC分类号： A61K948

CPC分类号： A61K9/4833 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  Y10S514/937

摘要： The invention concerns liquid or pasty thixotropic compositions containing an active substance for filling capsules at room temperature. The compositions become fluid by the effect of shearing when they pass through the filling nozzle, then recover their consistency with sufficient intensity and rapidity to prevent, after filling any leak between the two capsule parts. Said compositions are characterized in that their rheological properties are specially adapted for filling and for optimal recovery of consistency. They are preferably in the form of dispersions supporting amphiphilic excipients. Said compositions enable the formulation of active liquid, pasty and even solid substances.

摘要翻译： 本发明涉及含有用于在室温下填充胶囊的活性物质的液体或膏状触变组合物。 当组合物通过填充喷嘴时，组合物变得流动，然后以足够的强度和快速恢复其稠度，以防止在两个胶囊部件之间填充任何泄漏之后。 所述组合物的特征在于它们的流变特性特别适用于填充和最佳恢复稠度。 它们优选为支持两亲性赋形剂的分散体的形式。 所述组合物能够制备活性液体，糊状甚至固体物质。

公开(公告)号：US06709674B2

公开(公告)日：2004-03-23

申请号：US10137205

申请日：2002-05-01

申请人： Dorla Mirejovsky

发明人： Dorla Mirejovsky

IPC分类号： A61K948

CPC分类号： A61K47/12 ,  A61K9/0019 ,  A61K31/66 ,  A61K47/02 ,  A61K47/26

摘要： The invention includes a packaged liquid composition of a pamidronate alkaline salt in a sealed storage vessel having an inner surface which is non-reactive with the pamidronate alkaline salt composition.

摘要翻译： 本发明包括在密封储存容器中的帕米膦酸盐碱盐的包装液体组合物，其具有与帕米膦酸盐碱性盐组合物不反应的内表面。

公开(公告)号：US06656501B1

公开(公告)日：2003-12-02

申请号：US09614243

申请日：2000-07-12

申请人： John T. Cooker

发明人： John T. Cooker

IPC分类号： A61K948

CPC分类号： A61K9/4808

摘要： The present invention is directed to improved oral dosage forms that are significantly easier to swallow. In accordance with the present invention, the oral dosage forms are configured to have relatively greater weight and/or density to effect partial or total submergence in the liquid with which the oral dosage form is taken. In one embodiment, a filler is added to the ingredients of the oral dosage form. In another embodiment, a filler is added to the medium of the oral dosage form. In a further embodiment, a filler is added to the exterior of the oral dosage form. In another embodiment, a relatively heavier, denser or larger amount of ingredient is used to formulate the oral dosage form. In yet a further embodiment, a binder is used to increase the weight and/or density of the oral dosage form. In yet another embodiment, a combination comprising a binder and a relatively heavier, denser or larger amount of ingredient is used to formulate the oral dosage form. In accordance with the present invention, oral dosage forms are configured to have a predetermined weight and/or density while conforming its size to what can be comfortably swallowed.

摘要翻译： 本发明涉及显着更容易吞咽的改进的口服剂型。 根据本发明，口服剂型被配置为具有相对较大的重量和/或密度，以进行采用口服剂型的液体的部分或全部浸没。 在一个实施方案中，将填料加入到口服剂型的成分中。 在另一个实施方案中，将填料加入到口服剂型的培养基中。 在另一个实施方案中，将填料加入口服剂型的外部。 在另一个实施方案中，使用相对较重，更致密或更大量的成分来配制口服剂型。 在又一个实施方案中，使用粘合剂来增加口服剂型的重量和/或密度。 在另一个实施方案中，使用包含粘合剂和相对较重，更致密或更大量的成分的组合来配制口服剂型。 根据本发明，口服剂型被配置为具有预定的重量和/或密度，同时使其尺寸符合可舒适地吞咽的尺寸。

公开(公告)号：US06656500B2

公开(公告)日：2003-12-02

申请号：US09760133

申请日：2001-01-12

申请人： Bruce A. Firestone ,  Thao T. Tran

发明人： Bruce A. Firestone ,  Thao T. Tran

IPC分类号： A61K948

CPC分类号： A61K9/4841 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/4858 ,  A61K31/4436 ,  A61K31/455

摘要： A capsule system for oral delivery of an active agent having low aqueous solubility generally includes, in combination with the active agent, a vehicle for preventing initial active agent dissolution within the gastrointestinal tract and an emulsifier for promoting self-emulsification of the active agent and vehicle in the gastrointestinal tract. A capsule shell is provided for encapsulating the active agent, vehicle and emulsifier with the shell being formulated to open upon ingestion into the gastrointestinal tract and release the active agent and vehicle.

摘要翻译： 用于口服递送低水溶性活性剂的胶囊系统通常包括与活性剂组合用于防止初始活性剂溶解在胃肠道内的载体和用于促进活性剂和载体的自乳化的乳化剂 在胃肠道。 提供胶囊壳，用于包封活性剂，载体和乳化剂，其中壳被配制成在摄入胃肠道时开放并释放活性剂和载体。

公开(公告)号：US06652879B2

公开(公告)日：2003-11-25

申请号：US10041877

申请日：2001-10-22

申请人： Joar Opheim

发明人： Joar Opheim

IPC分类号： A61K948

CPC分类号： A61K47/46 ,  A61K9/4816 ,  A61K35/60

摘要： A flavored gelatin capsule and the method of manufacture of the flavored capsule is provided. The capsule may comprise (a) from about 10 to about 70 parts by weight of gelatin; (b) from about 10 to about 35 parts by weight of a suitable polyol, such as glycerol; (c) from about 8 parts by weight of water; and (c) various parts by weight of particular water soluble flavorings. The contents of the capsule may also be flavored. The composition is particularly useful in improving the palatability of fish oil medicinals.

公开(公告)号：US06630160B1

公开(公告)日：2003-10-07

申请号：US09654802

申请日：2000-09-05

申请人： Steven Evans ,  Jerome Bernard Block

发明人： Steven Evans ,  Jerome Bernard Block

IPC分类号： A61K948

CPC分类号： A23L33/105 ,  A23L31/00 ,  A23V2002/00 ,  A23V2250/213 ,  A23V2250/712 ,  A23V2250/1626 ,  A23V2250/214 ,  A23V2250/2132 ,  A23V2250/314 ,  A23V2250/212

摘要： A dietary supplement is created, comprised of material from the following nutrients, vitamins, herbs, minerals, and food and plant substances and food and plant derivatives: lycopene, vitamin E, selenium, green tea, coenzyme Q10, garlic, folic acid, vitamin C, curcumin, seaweed, Cordyceps sinsensis mushroom, Lentinus edodes (shiitake) mushroom, and Ganoderma lucidum (reishi) mushroom. The composition is administered orally for individuals who wish to reduce their risk of disease, particularly cancer-risk.

摘要翻译： 营养补充剂由以下营养素，维生素，草药，矿物质，食物和植物物质以及食品和植物衍生物组成：番茄红素，维生素E，硒，绿茶，辅酶Q10，大蒜，叶酸，维生素 C，姜黄素，海藻，冬虫夏草，香菇（香菇）蘑菇，灵芝蘑菇。 组合物口服给予希望降低其疾病风险，特别是癌症风险的个体。

公开(公告)号：US06627219B2

公开(公告)日：2003-09-30

申请号：US09896103

申请日：2001-06-29

申请人： Wei-Hua Hao ,  Shih Min Chen

发明人： Wei-Hua Hao ,  Shih Min Chen

IPC分类号： A61K948

CPC分类号： A61K9/4891 ,  A61K9/4858 ,  A61K31/4439

摘要： The present invention provides a oral capsule preparation, comprising a capsule prepared from a drug or the alkaline salt thereof, an oily compound or the alkaline salt thereof, an emulsifier and a polycarbon alcohol, together with an enteric coating disposed on the outer layer of the capsule; wherein said emulsifier is a composition of C6-18 organic fatty acid and an organic amine, or the mixture thereof. The invention also provides a method of preparing the oral capsule preparation of the invention.

公开(公告)号：US06569453B2

公开(公告)日：2003-05-27

申请号：US09983990

申请日：2001-10-26

申请人： Rudolf Linder ,  Rango Dietrich

发明人： Rudolf Linder ,  Rango Dietrich

IPC分类号： A61K948

CPC分类号： A61K9/2081 ,  A61K9/0007 ,  A61K9/0031 ,  A61K9/025 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5047 ,  A61K31/4439

摘要： An administration form for acid-labile active compounds are described. The administration forms have no enteric layers and are suitable for oral administration.

摘要翻译： 描述了酸不稳定活性化合物的给药形式。 给药形式没有肠溶层，适合口服。