公开(公告)号：US07635708B2

公开(公告)日：2009-12-22

申请号：US10324744

申请日：2002-12-19

申请人： Bruce M. Spiegelman ,  Elisabetta Mueller ,  Pasha Sarraf ,  Soner Altiok ,  Peter Tontonoz ,  Samuel Singer

发明人： Bruce M. Spiegelman ,  Elisabetta Mueller ,  Pasha Sarraf ,  Soner Altiok ,  Peter Tontonoz ,  Samuel Singer

IPC分类号： A61K31/675 ,  A61K31/41 ,  A61K31/425 ,  A61K31/28 ,  A61K33/24 ,  A01N57/00 ,  A01N43/82 ,  A01N43/78 ,  A01N55/02

CPC分类号： A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K45/06 ,  Y10S514/908

摘要： The present invention is based on the finding that activation of PPARγ plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPARγ agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proliferation of such cells.

摘要翻译： 本发明基于以下发现：PPARγ的激活在诱导某些主动增殖细胞的生长停滞和分化中起关键作用。 我们显示PPARγ激动剂如噻唑烷二酮配体（TZD）的施用在体外和体内都有效抑制这些细胞的增殖。

公开(公告)号：US06552055B2

公开(公告)日：2003-04-22

申请号：US08923346

申请日：1997-09-04

申请人： Bruce M. Spiegelman ,  Elisabetta Mueller ,  Pasha Sarraf ,  Soner Altiok ,  Peter Tontonoz ,  Samuel Singer

发明人： Bruce M. Spiegelman ,  Elisabetta Mueller ,  Pasha Sarraf ,  Soner Altiok ,  Peter Tontonoz ,  Samuel Singer

IPC分类号： A61K3144

CPC分类号： A61K45/06 ,  A61K31/426 ,  A61K31/427

摘要： The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.

公开(公告)号：US06242196B1

公开(公告)日：2001-06-05

申请号：US09319769

申请日：1999-09-17

申请人： Bruce M. Spiegelman ,  Soner Altiok ,  Elisabetta Mueller ,  Pasha Sarraf ,  Peter Tontonoz

发明人： Bruce M. Spiegelman ,  Soner Altiok ,  Elisabetta Mueller ,  Pasha Sarraf ,  Peter Tontonoz

IPC分类号： C12Q134

CPC分类号： A61K31/426

摘要： A method for inhibiting proliferation of a PPAR &ggr;-responsive hyperproliferative cell which comprises the step of contacting the cell with (I) an inhibitory amount of a PPAR&ggr; agonist and (II) a MAP kinase inhibitor is disclosed. A method for treating or prophylactically preventing in an animal subject a disorder characterized by unwanted proliferation of PPAR&ggr;-responsive hyperproliferative cells which comprises administering to the subject (I) an inhibitory amount of a PPAR&ggr; agonist and (II) a MAP kinase inhibitor is also disclosed. Pharmaceutical compositions comprising a therapeutically effective amount of a PPAR&ggr; agonist and a MAP kinase inhibitor are disclosed for use in the methods.

摘要翻译： 公开了一种抑制PPARγ反应性过度增殖细胞增殖的方法，其包括使细胞与（I）抑制量的PPARγ激动剂和（II）MAP激酶抑制剂接触的步骤。 一种用于在动物受试者中治疗或预防性地预防PPARγ反应性过度增殖性细胞不希望的增殖的病症的方法，其包括对受试者（I）施用抑制量的PPARγ激动剂和（II）MAP激酶抑制剂 。 公开了包含治疗有效量的PPARγ激动剂和MAP激酶抑制剂的药物组合物用于该方法。