公开(公告)号：US20110171645A1

公开(公告)日：2011-07-14

申请号：US12937220

申请日：2009-04-09

申请人： Bruce McManus ,  Zsuzsanna Hollander ,  Alice Mui ,  Robert Balshaw ,  Robert Mcmaster ,  Paul Keown ,  Gabriela Cohen Freue ,  Pooran Qasimi ,  Raymond Ng ,  David Lin ,  David Wishart ,  Axel Bergman

发明人： Bruce McManus ,  Zsuzsanna Hollander ,  Alice Mui ,  Robert Balshaw ,  Robert Mcmaster ,  Paul Keown ,  Gabriela Cohen Freue ,  Pooran Qasimi ,  Raymond Ng ,  David Lin ,  David Wishart ,  Axel Bergman

IPC分类号： C12Q1/68 ,  G01N33/53 ,  H01J49/26

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/505 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2800/245 ,  G01N2800/32

摘要： The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling,

摘要翻译： 本发明涉及使用基因组表达谱，蛋白质组表达谱，代谢物分析或同种异体反应性T细胞基因组表达谱来诊断心脏同种异体移植物的急性排斥反应的方法，

公开(公告)号：US20050075796A1

公开(公告)日：2005-04-07

申请号：US10615342

申请日：2003-07-07

申请人： David Wishart ,  Russell Greiner ,  Tim Rosborough ,  Brent Lefebvre ,  Noah Epstein ,  Jack Newton ,  Warren Wong

发明人： David Wishart ,  Russell Greiner ,  Tim Rosborough ,  Brent Lefebvre ,  Noah Epstein ,  Jack Newton ,  Warren Wong

IPC分类号： G01N33/483 ,  G06F19/00

CPC分类号： G01R33/4625 ,  Y10T436/24

摘要： A computer implemented process for producing a representation of a reference spectrum for a reference solution having a first pH condition, for use in determining the composition of a test sample, is disclosed. The process involves producing a position value for at least one peak of the reference spectrum in response to a measured pH condition of the test sample, and a property of at least one peak in a base reference spectrum for the reference solution, the base reference spectrum being associated with a pH condition of the reference solution that is different from said measured pH condition.

摘要翻译： 公开了一种计算机实现的方法，用于产生用于具有第一pH条件的参考溶液的参考光谱的表示，用于确定测试样品的组成。 该方法包括响应于测试样品的测量的pH条件产生参考光谱的至少一个峰的位置值，以及用于参考溶液的基准参考光谱中的至少一个峰的性质，基准参考光谱 与参考溶液的pH条件相关，其不同于所测量的pH条件。

公开(公告)号：US20050075797A1

公开(公告)日：2005-04-07

申请号：US10615416

申请日：2003-07-07

申请人： David Wishart ,  Russell Greiner ,  Tim Rosborough ,  Brent Lefebvre ,  Noah Epstein ,  Jack Newton ,  Warren Wong

发明人： David Wishart ,  Russell Greiner ,  Tim Rosborough ,  Brent Lefebvre ,  Noah Epstein ,  Jack Newton ,  Warren Wong

IPC分类号： G01N33/483 ,  G06F19/00 ,  G01N31/00

CPC分类号： G01R33/4625 ,  Y10T436/24

摘要： A process for quantitative and qualitative analysis for identifying compounds in a sample mixture involves the identification of a set of reference spectra selected according to a measured condition of the sample, which collectively define a composite spectrum which best matches a spectrum produced from the sample. The compounds associated with respective reference spectra of the identified set are the compounds that are determined to be likely to be present in the sample. Quantities of the compounds may be determined from the intensities of certain representative peaks associated with the compounds, relative to the intensity of a peak associated with a reference compound which is unaffected by the measured condition of the sample. A measured condition may be pH of the sample, for example, and an accurate measurement of pH can be obtained from the test spectrum. Thus, given a test spectrum of a sample and given a set of reference spectra, the process can identify and quantify compounds present in the sample. A process for producing reference spectra as a function of condition factor is also disclosed and a process for automatically pre-processing a spectrum from an NMR system is disclosed.

摘要翻译： 用于鉴定样品混合物中化合物的定量和定性分析方法包括鉴定根据样品的测量条件选择的一组参考光谱，其共同定义与样品产生的光谱最佳匹配的复合光谱。 与鉴定的组的相应参考光谱相关的化合物是被确定为可能存在于样品中的化合物。 化合物的量可以从与化合物相关的某些代表性峰的强度相对于与不受样品测量条件影响的参考化合物相关的峰的强度来确定。 例如，测量条件可以是样品的pH，并且可以从测试光谱获得pH的精确测量。 因此，给定样品的测试光谱并给出一组参考光谱，该过程可以鉴定和定量样品中存在的化合物。 还公开了作为条件因子的函数产生参考光谱的方法，并且公开了从NMR系统自动预处理光谱的方法。