公开(公告)号：US12146929B2

公开(公告)日：2024-11-19

申请号：US18066381

申请日：2022-12-15

Applicant: Bruker BioSpin GmbH

Inventor： Alexander Krahn ,  David Osen ,  Priyanga Bandara ,  Jürgen Ganz

IPC: G01R33/30 ,  G01R33/31

Abstract: An apparatus for detachably fastening an NMR probe head with a pedestal box to an NMR magnet system of an NMR spectrometer has a holding system rigidly connected to the magnet system. A base plate of the holding system fastens detachably to the probe head pedestal box. A receiving device on or in the base plate receives all electric, electronic, optical, pneumatic, and thermal feed lines and optionally discharge lines required for the operation of the probe head. A lower side of the base plate in contact with an upper side of the pedestal box comprises multiple connecting elements into which the feed lines and discharge lines merge. The upper side of the pedestal box comprises receiving elements into which the feed lines and discharge lines from the connecting elements merge in a predetermined relative assembled position.

公开(公告)号：US11187767B2

公开(公告)日：2021-11-30

申请号：US16790889

申请日：2020-02-14

Applicant: Bruker BioSpin GmbH

Inventor： David Osen ,  Alexander Krahn ,  Constantin Schalck

IPC: G01R33/30 ,  G01R33/31

Abstract: An MAS probehead (1) positioned in a magnet bore (2) includes a sample chamber (3) with a stator (4) for receiving a rotor and an RF coil that radiates RF pulses into and/or receives RF signals from an NMR sample (5). A temperature-control apparatus guides gas at a first variable temperature T1 into the sample chamber and through the stator during an NMR measurement, and guides a pressurized gas stream at a second variable temperature T2 around the sample chamber. The sample chamber is surrounded by an encapsulation device (6), at least in the azimuthal direction around the axis of the magnet bore and counter to the flow direction of the pressurized gas, and is oriented to provide an air gap (7′) between the sample chamber and the magnet bore. This prevents dissipation of the gas temperature to outer parts of the probehead, and yields larger NMR measurement temperature ranges.

公开(公告)号：US20160334478A1

公开(公告)日：2016-11-17

申请号：US15152573

申请日：2016-05-12

Applicant: Bruker BioSpin GmbH

Inventor： David Osen ,  Benno Knott ,  Armin Purea

IPC: G01R33/30

CPC classification number: G01R33/307 ,  G01R33/302 ,  G01R33/44

Abstract: An MAS stator (7) for an NMR-MAS probe head (1) has a bottom bearing (8) with at least one nozzle and at least one radial bearing (9a, 9b), wherein one substantially circular cylindrical MAS rotor (21c) is provided for receiving a measurement substance. The MAS rotor can be supported by compressed gas in a measurement position within the MAS stator by means of a gas supply device and can be rotated about the cylinder axis of the MAS rotor by means of a pneumatic drive. A suction device (100) is provided in a space below the radial bearing for suctioning-off the gas introduced by the gas supply device, and generates an underpressure in the space below the radial bearing during measurement operation. This provides a stator for NMR-MAS spectroscopy in which the closure at the head end of the stator is omitted.

Abstract translation: 用于NMR-MAS探针头（1）的MAS定子（7）具有带有至少一个喷嘴和至少一个径向轴承（9a，9b）的底部轴承（8），其中一个基本圆形的圆柱形MAS转子（21c） 被提供用于接收测量物质。 MAS转子可以通过气体供应装置在MAS定子内的测量位置由压缩气体支撑，并且可以通过气动驱动器围绕MAS转子的气缸轴线旋转。 抽吸装置（100）设置在径向轴承下方的空间中，用于抽吸由气体供应装置引入的气体，并且在测量操作期间在径向轴承下方的空间中产生负压。 这提供了用于NMR-MAS光谱的定子，其中在定子的头端处的封闭件被省略。

公开(公告)号：US10241162B2

公开(公告)日：2019-03-26

申请号：US15086395

申请日：2016-03-31

Applicant: Bruker BioSpin GmbH

Inventor： David Osen ,  Benno Knott

IPC: G01R33/30 ,  F01D5/02 ,  F01D5/14 ,  F01D9/02 ,  F01D25/16

Abstract: A nuclear magnetic resonance-magic angle spinning (NMR-MAS) turbine assembly has a MAS rotor with turbine cap having a stopper region and a turbine region. The stopper region allows feeding into a rotor tube and has at least one sealing section for resting against an inner wall of the rotor tube. The turbine region has a collar section for resting against a face side of the rotor tube and a turbine section that forms the turbine blades, which protrude axially from the collar section without extending radially further than the collar section. The arrangement of the rotor allows for very high rotation frequencies that, correspondingly, reduce line broadening in NMR measurements.

公开(公告)号：US20140125340A1

公开(公告)日：2014-05-08

申请号：US14156473

申请日：2014-01-16

Applicant: BRUKER BIOSPIN GMBH

Inventor： Andreas Hunkeler ,  Benno Knott ,  David Osen

IPC: G01R33/34

CPC classification number: G01R33/307 ,  G01R33/31 ,  G01R33/34092

Abstract: An NMR MAS probe head (1) has an MAS stator (7) with a base bearing (8) and a front bearing (75) for receiving a substance to be measured at a measurement position within an MAS rotor. The front bearing has an opening for inserting the MAS rotor into the space between the base bearing and the front bearing. The opening can be closed by a closing device that, in a loading state, opens and, in a measuring state, closes the opening by means of a movement that is transverse with respect to an axis (a) through the centers of the base bearing and the opening of the front bearing of the MAS stator. This enables automated loading and unloading of the MAS rotor in the space between the base bearing and the front bearing inside the MAS stator in a simple way.

Abstract translation: NMR MAS探针头（1）具有带有基座轴承（8）的MAS定子（7）和用于在MAS转子内的测量位置接收待测量物质的前轴承（75）。 前轴承具有用于将MAS转子插入基座轴承和前轴承之间的空间的开口。 关闭装置可以通过闭合装置关闭，该关闭装置在装载状态下打开，并且在测量状态下通过相对于轴线（a）穿过基座轴承的中心的移动来关闭开口 和MAS定子的前轴承的开口。 这使得能够以简单的方式在MAS定子内的基座轴承和前轴承之间的空间中自动加载和卸载MAS转子。

公开(公告)号：US10768248B2

公开(公告)日：2020-09-08

申请号：US16285360

申请日：2019-02-26

Applicant: Bruker BioSpin GmbH

Inventor： Priyanga Bandara ,  Ralf Haueisen ,  Juergen Ganz ,  David Osen ,  Martin Armbruster ,  Alexander Krahn

IPC: G01R33/30 ,  G01R33/31 ,  G01R33/46 ,  G01R33/422

Abstract: An NMR probe head (1) having an RF coil arrangement (2a) in a coil region (2) and an RF shielding tube (3) for supply lines leading from a connection region (4) to the coil region. An elongated backbone (5) is arranged inside the shielding tube and has an inherently rigid, mechanically stiff structure having continuous bores and/or connecting channels (5a) which run parallel to the tube axis and accommodate the supply lines. The backbone has a continuously electrically conductive outer surface which leads from the connection region to the coil region and is electrically conductively connected to the conductive inner surface of the shielding tube via connecting elements (6). A continuous electrically conductive contour is formed thereby between the backbone and the shielding tube. This shields against externally incident RF fields and spatially separates the stable mechanical supporting construction and the supply lines from the electronic and RF components.

公开(公告)号：US10712410B2

公开(公告)日：2020-07-14

申请号：US16271032

申请日：2019-02-08

Applicant: Bruker BioSpin GmbH

Inventor： Alexander Krahn ,  David Osen ,  Armin Purea ,  Markus Mayer ,  Roger Meister

IPC: G01R33/30

Abstract: A probe head (1) of an NMR-MAS assembly has a stator (2) with an opening (4) receiving a rotor (3) which, in a measuring position, rotates at the magic angle to the B0 field. The stator is pivotable between the measuring position and a loading position of the rotor. A detection device (5) permits external, contactless identification of whether the opening of the stator is fitted with a rotor. The detection device has a light source (5a), from which light is introduced into a lower end (6″) of a light guide (6). The stator has a first bore (2a), in which a first light guide stump (7a) is positioned such that, in the loading position of the stator, it produces an optical connection between a rotor inserted in the stator and an upper end (6′) of the light guide opposite the lower end.

公开(公告)号：US10459044B2

公开(公告)日：2019-10-29

申请号：US15718723

申请日：2017-09-28

Applicant: Bruker BioSpin GmbH

Inventor： David Osen ,  Armin Purea ,  Benno Knott ,  Fabian Kuehler ,  Florian Helbing ,  Alia Hassan ,  Jevgeni Guidoulianov ,  Nicolas Freytag

IPC: G01R33/31 ,  G01R33/30

Abstract: A method for operating an NMR probehead (10) with an MAS stator (11) receiving a circular-cylindrical hollow MAS rotor (13) with an outer jacket. The MAS rotor is mounted on pressurized gas in a measuring position within the MAS stator via a gas supply device with a bearing nozzle (12′) and rotates about the cylinder axis of the MAS rotor at a rotation frequency f≥30 kHz. During a measurement, a temperature control gas is blown by a temperature control nozzle (12) onto the outer jacket of the rotor at an angle α

公开(公告)号：US10132881B2

公开(公告)日：2018-11-20

申请号：US15152573

申请日：2016-05-12

Applicant: Bruker BioSpin GmbH

Inventor： David Osen ,  Benno Knott ,  Armin Purea

IPC: G01R33/30 ,  G01R33/44

Abstract: An MAS stator (7) for an NMR-MAS probe head (1) has a bottom bearing (8) with at least one nozzle and at least one radial bearing (9a, 9b), wherein one substantially circular cylindrical MAS rotor (21c) is provided for receiving a measurement substance. The MAS rotor can be supported by compressed gas in a measurement position within the MAS stator by means of a gas supply device and can be rotated about the cylinder axis of the MAS rotor by means of a pneumatic drive. A suction device (100) is provided in a space below the radial bearing for suctioning-off the gas introduced by the gas supply device, and generates an underpressure in the space below the radial bearing during measurement operation. This provides a stator for NMR-MAS spectroscopy in which the closure at the head end of the stator is omitted.

公开(公告)号：US09778331B2

公开(公告)日：2017-10-03

申请号：US14156473

申请日：2014-01-16

Applicant: BRUKER BIOSPIN GMBH

Inventor： Andreas Hunkeler ,  Benno Knott ,  David Osen

IPC: G01R33/30 ,  G01R33/31 ,  G01R33/34

CPC classification number: G01R33/307 ,  G01R33/31 ,  G01R33/34092

Abstract: An NMR MAS probe head (1) has an MAS stator (7) with a base bearing (8) and a front bearing (75) for receiving a substance to be measured at a measurement position within an MAS rotor. The front bearing has an opening for inserting the MAS rotor into the space between the base bearing and the front bearing. The opening can be closed by a closing device that, in a loading state, opens and, in a measuring state, closes the opening by means of a movement that is transverse with respect to an axis (a) through the centers of the base bearing and the opening of the front bearing of the MAS stator. This enables automated loading and unloading of the MAS rotor in the space between the base bearing and the front bearing inside the MAS stator in a simple way.