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公开(公告)号：US11583817B2
公开(公告)日：2023-02-21
申请号：US16969874
申请日：2019-03-04
发明人： Chase McTaggart , Brian Hodges , Charles Koetting , Frederick M. MacDonnell , Brian Dennis , Mark Hulsizer
摘要： A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.
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公开(公告)号：US20150152390A1
公开(公告)日：2015-06-04
申请号：US14531774
申请日：2014-11-03
IPC分类号： C12N5/09
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译： 提供了修改一个或多个生物靶标的组合物和方法。 合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。 组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。 组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。 氧化还原活性配体有助于保持多于一个钌原子的分离。 合适的组合物还可以包括包含杂环芳族化合物的末端配体。 当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。 合适的组合物通常在还原剂存在下是催化和再生的。
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公开(公告)号：US09816075B2
公开(公告)日：2017-11-14
申请号：US14531774
申请日：2014-11-03
IPC分类号： A61K9/00 , C12N5/09 , C07F15/00 , A61K31/435 , A61K49/00
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
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公开(公告)号：US11110438B2
公开(公告)日：2021-09-07
申请号：US16528124
申请日：2019-07-31
摘要： Described herein are catalysts relating to liquid synthesis, methods of their preparation, and methods of their use. In an embodiment according to the present disclosure, a method of producing a catalyst for liquid synthesis comprises: providing a silica oxide support; pretreating the silica oxide support to remove air and moisture; impregnating the pretreated silica oxide support with cobalt from a cobalt source using a cobalt impregnation method; and calcinating the impregnated silica oxide support in an oven with a temperature ramping profile, wherein the calcinating comprises feeding air into the oven.
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公开(公告)号：US20200038846A1
公开(公告)日：2020-02-06
申请号：US16528124
申请日：2019-07-31
摘要： Described herein are catalysts relating to liquid synthesis, methods of their preparation, and methods of their use. In an embodiment according to the present disclosure, a method of producing a catalyst for liquid synthesis comprises: providing a silica oxide support; pretreating the silica oxide support to remove air and moisture; impregnating the pretreated silica oxide support with cobalt from a cobalt source using a cobalt impregnation method; and calcinating the impregnated silica oxide support in an oven with a temperature ramping profile, wherein the calcinating comprises feeding air into the oven.
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