公开(公告)号：US20210261739A1

公开(公告)日：2021-08-26

申请号：US17308599

申请日：2021-05-05

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US11041050B2

公开(公告)日：2021-06-22

申请号：US16880065

申请日：2020-05-21

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US20190202995A1

公开(公告)日：2019-07-04

申请号：US16351168

申请日：2019-03-12

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  C08J3/12 ,  A61K9/50 ,  A61K47/34 ,  C08G79/08 ,  C08G69/40 ,  C08G73/02

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US20200283582A1

公开(公告)日：2020-09-10

申请号：US16880065

申请日：2020-05-21

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US10717825B2

公开(公告)日：2020-07-21

申请号：US16351168

申请日：2019-03-12

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US10287401B2

公开(公告)日：2019-05-14

申请号：US15180201

申请日：2016-06-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to polymer and polymer conjugate-based nanoparticle delivery systems for delivering biological agents, and methods of making and using these compositions. Certain embodiments of the present disclosure provide polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) or Formula (II) or Formula (III): wherein is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.