公开(公告)号：US20190117773A1

公开(公告)日：2019-04-25

申请号：US16200095

申请日：2018-11-26

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K45/06 ,  A61K47/69 ,  A61K47/60 ,  A61K9/51 ,  A61K31/4745 ,  A61K31/337 ,  A61K31/727

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

公开(公告)号：US09468681B2

公开(公告)日：2016-10-18

申请号：US13782458

申请日：2013-03-01

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K45/06 ,  A61K31/337 ,  A61K31/727 ,  A61K47/48 ,  A61K9/51

CPC classification number: A61K45/06 ,  A61K9/5161 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/60 ,  A61K47/6935 ,  A61K2300/00

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US09446149B2

公开(公告)日：2016-09-20

申请号：US14805640

申请日：2015-07-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K47/48 ,  A61K31/337 ,  A61K9/51 ,  A61K31/713 ,  A61K31/4745 ,  A61K31/427 ,  C08G81/00 ,  C12N15/113 ,  A61K9/19

CPC classification number: A61K47/48907 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K47/6935 ,  C08G81/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

Abstract: Described herein are polymer conjugates comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic acid.

Abstract translation: 本文描述的是包含含有与含有硝基硼酸的聚合物偶合的多元醇的聚合物的聚合物共轭物。

公开(公告)号：US20140249203A1

公开(公告)日：2014-09-04

申请号：US13782486

申请日：2013-03-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K9/51 ,  A61K31/4745 ,  A61K31/427 ,  A61K31/713

CPC classification number: A61K47/48907 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K47/6935 ,  C08G81/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US20140249202A1

公开(公告)日：2014-09-04

申请号：US13782458

申请日：2013-03-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K47/34 ,  A61K45/06 ,  A61K31/713

CPC classification number: A61K45/06 ,  A61K9/5161 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/60 ,  A61K47/6935 ,  A61K2300/00

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US11285212B2

公开(公告)日：2022-03-29

申请号：US16200095

申请日：2018-11-26

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K45/06 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K9/51 ,  A61K47/60 ,  A61K47/69

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

公开(公告)号：US09132097B2

公开(公告)日：2015-09-15

申请号：US13782486

申请日：2013-03-01

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K9/51 ,  A61K31/337 ,  A61K9/19

CPC classification number: A61K47/48907 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K47/6935 ,  C08G81/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US20210283258A1

公开(公告)日：2021-09-16

申请号：US17325292

申请日：2021-05-20

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K45/06 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K9/51 ,  A61K47/60 ,  A61K47/69

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

公开(公告)号：US10166291B2

公开(公告)日：2019-01-01

申请号：US15291485

申请日：2016-10-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K31/427 ,  A61K45/06 ,  A61K31/337 ,  A61K31/731 ,  A61K31/4745 ,  A61K9/51 ,  A61K31/727 ,  A61K47/60 ,  A61K47/69

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.