公开(公告)号：US09809528B2

公开(公告)日：2017-11-07

申请号：US15207822

申请日：2016-07-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Marat Orazov ,  Mark E. Davis

IPC: C07C67/00 ,  C07C51/00

CPC classification number: C07C67/00 ,  C07C51/00 ,  C07C59/08 ,  C07C69/68

Abstract: The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a tandem catalyst system comprising retro-aldol catalysts and Lewis acid catalysts. In some embodiments, these alpha-hydroxy carboxylic acids may be prepared from pentoses and hexoses. The retro-aldol and Lewis catalysts may be characterized by their respective ability to catalyze a 1,2-carbon shift reaction and a 1,2-hydride shift reaction on an aldose or ketose substrate.