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公开(公告)号：US12103912B2
公开(公告)日：2024-10-01
申请号：US17663071
申请日：2022-05-12
Applicant: CARGILL, INCORPORATED
Inventor： Timothy Walter Abraham , Ravi R. Gokarn
CPC classification number: C07C67/08 , C07C67/03 , C07C67/54 , C07C67/03 , C07C69/68 , C07C67/54 , C07C69/68
Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxycarboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxycarboxylic acid recovery bottom, adding a mono-alcohol to the hydroxycarboxylic acid recovery bottom to obtain a first mixture, heating the first mixture, optionally in the presence of a catalyst, to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
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公开(公告)号：US11802105B2
公开(公告)日：2023-10-31
申请号：US17207975
申请日：2021-03-22
Applicant: CORSAIR PHARMA, INC.
Inventor： Xiaoming Zhang , Meenakshi S. Venkatraman , Cyrus K. Becker
IPC: C07C69/734 , C07C69/675 , C07C69/68 , C07D305/08 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
CPC classification number: C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20180162797A1
公开(公告)日：2018-06-14
申请号：US15577912
申请日：2016-05-30
Applicant: Arvind Mallinath LALI
Inventor： Arvind Mallinath LALI , Ritu Rahul MAURYA
CPC classification number: C07C51/09 , C07C51/42 , C07C51/46 , C07C67/03 , C07C67/08 , Y02P20/125 , C07C53/06 , C07C59/08 , C07C53/10 , C07C69/06 , C07C69/14 , C07C69/68 , C07C53/02 , C07C53/08 , C07C53/122 , C07C69/24
Abstract: The invention relates to a process for separation of organic acids from mixture of ammonium salts of one or more organic acids and other compounds via an integrated process. The process involves suspending mixture of ammonium salts of one or more organic acids and other compounds in dry hydrocarbon solvent/s or mixtures thereof; wherein the selected hydrocarbon solvent/s or mixtures thereof have boiling point more than 100° C. and forms an azeotrope with water. The reaction mixture thus obtained is dehydrated azeotropically followed by esterification of basic salt of the organic acids by addition of alcohol in presence of metal or metal salt; thereafter the individual esters formed are separated by distillation and hydrolysed to obtain corresponding organic acids having more than 98% purity.
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公开(公告)号：US20170253553A1
公开(公告)日：2017-09-07
申请号：US15511158
申请日：2015-09-17
Applicant: NIPPON SHOKUBAI CO., LTD.
Inventor： Hisashi KAMEI , Hiroshi YOSHIDA
Abstract: The method for producing a vapor composition containing lactic acid of the present invention is capable of suppressing the generation of by-products such as acetaldehyde and carbon monoxide due to pyrolysis of a lactic acid species during vaporization. Furthermore, a lactic acid oligomer generated can be effectively used without loss, and a vapor composition containing lactic acid can be industrially efficiently produced stably for a long time. The present invention relates to a method for producing a vapor composition containing lactic acid including: feeding a liquid composition containing lactic acid to a vaporizer; mixing the liquid composition with a liquid composition containing a lactic acid oligomer contained in the vaporizer to prepare a liquid mixture; and heating the liquid mixture to vaporize part of the liquid mixture, whereby a vapor composition containing lactic acid is produced.
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5.发明申请PRODUCTION OF ALPHA-HYDROXY CARBOXYLIC AIDS AND ESTERS FROM HIGHER SUGARS USING TANDEM CATALYST SYSTEMS 有权使用TANDEM催化剂体系从高级糖生产ALPHA-羟基羧酸和艾司公开(公告)号：US20170015614A1
公开(公告)日：2017-01-19
申请号：US15207822
申请日：2016-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： MARAT ORAZOV , MARK E. DAVIS
Abstract: The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a tandem catalyst system comprising retro-aldol catalysts and Lewis acid catalysts. In some embodiments, these alpha-hydroxy carboxylic acids may be prepared from pentoses and hexoses. The retro-aldol and Lewis catalysts may be characterized by their respective ability to catalyze a 1,2-carbon shift reaction and a 1,2-hydride shift reaction on an aldose or ketose substrate.
Abstract translation: 本公开涉及用于使用包含反醛醇二醇催化剂和路易斯酸催化剂的串联催化剂体系从较高糖制备α-羟基羧酸和酯的方法和组合物。 在一些实施方案中，这些α-羟基羧酸可以由戊糖和己糖制备。 反醛醇醛和路易斯催化剂的特征可以在于其在醛糖或酮糖底物上催化1,2-碳转移反应和1,2-氢化物位移反应的能力。
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Patent Agency Ranking
公开(公告)号：US20160272569A1
公开(公告)日：2016-09-22
申请号：US15029357
申请日：2014-10-17
Applicant: CARGILL, INCORPORATED
Inventor： Timothy Walter ABRAHAM , Ravi R. GOKARN
Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, beating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
Abstract translation: 用羟基羧酸回收底物制备羟基链烷酸烷基酯的方法和系统。 所述方法通常包括获得羟基羧酸回收底部的步骤，向羟基羧酸回收底部加入单醇以获得第一混合物，在催化剂存在下击打第一混合物以形成反应产物，蒸馏 反应产物，并回收烷基羟基链烷酸酯部分。
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7.发明授权Method for synthesis of lactic acid and its derivatives and catalyst for preparing same 有权乳酸及其衍生物的合成方法及其制备催化剂公开(公告)号：US09422216B2
公开(公告)日：2016-08-23
申请号：US14424760
申请日：2013-08-27
Applicant: MICROVAST POWER SYSTEMS CO., LTD.
Inventor： Xiaoping Zhou
IPC: C07C51/00 , B01J27/00 , B01J27/138 , B01J27/135 , B01J27/125 , B01J27/132 , B01J27/08 , C01G30/00 , C01G19/06 , C01G9/04 , C01G37/04 , C01F7/56 , C01G3/05 , C01G19/08 , C01G19/00 , C01G51/08 , C07C67/00
CPC classification number: C07C51/00 , B01J27/08 , B01J27/125 , B01J27/132 , B01J27/135 , B01J27/138 , C01F7/56 , C01G3/05 , C01G9/04 , C01G19/00 , C01G19/06 , C01G19/08 , C01G30/007 , C01G37/04 , C01G51/085 , C07C67/00 , C07C59/08 , C07C69/68
Abstract: The present disclosure provides a catalyst for preparing lactic acid and derivatives thereof, comprising at least one of metallic compounds MXn, wherein M is selected from Na, K, Mg, Ca, Sr, Ba, Al, Ga, In, Sn, Sb, Bi, Cr, Mn, Fe, Co, Ni and Zn, and n is an integer of 1 to 6. The present disclosure further provides a method for synthesis of lactic acid and derivatives thereof, wherein at least one raw material including carbohydrates, at least one alcohol, at least one of the aforesaid catalysts and at least one solvent are heated to react to prepare lactic acid and derivatives thereof.
Abstract translation: 本发明提供了一种制备乳酸及其衍生物的催化剂，其包含至少一种金属化合物MXn，其中M选自Na，K，Mg，Ca，Sr，Ba，Al，Ga，In，Sn，Sb， Bi，Cr，Mn，Fe，Co，Ni和Zn，n为1〜6的整数。本发明还提供了一种乳酸及其衍生物的合成方法，其中，至少含有碳水化合物的原料， 至少一种醇，至少一种上述催化剂和至少一种溶剂被加热反应以制备乳酸及其衍生物。
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公开(公告)号：US20160229787A1
公开(公告)日：2016-08-11
申请号：US15029376
申请日：2014-10-17
Applicant: CARGILL, INCORPORATED
Inventor： Timothy Walter ABRAHAM , Anthony Louis DURAN , Stephen C. EDGAR , Ravi R. GOKARN
Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, heating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
Abstract translation: 用羟基羧酸回收底物制备羟基链烷酸烷基酯的方法和系统。 所述方法通常包括获得羟基羧酸回收底部的步骤，向羟基羧酸回收底部加入单醇以获得第一混合物，在催化剂存在下加热第一混合物以形成反应产物，蒸馏 反应产物，并回收烷基羟基链烷酸酯部分。
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公开(公告)号：US09334227B2
公开(公告)日：2016-05-10
申请号：US12084575
申请日：2006-11-08
Applicant: Graham Ronald Eastham , Mark Waugh , Philip Ian Richards
Inventor： Graham Ronald Eastham , Mark Waugh , Philip Ian Richards
CPC classification number: C07C67/31 , B01J31/2414 , C07C51/09 , C07C67/38 , C07C59/08 , C07C59/01 , C07C69/68 , C07C69/675 , C07C69/67
Abstract: A process for the carbonylation of ethylenically unsaturated compounds including vinyl esters and a process for the production of 3-hydroxy propanoate esters or acids. The process comprises reacting said compound with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a compound thereof: and (b) a bidentate ligand of general formula (I): X1(X2)-Q2-A-R—B-Q1-X3(X4).
Abstract translation: 包括乙烯基酯的烯属不饱和化合物的羰基化方法和用于制备3-羟基丙酸酯或酸的方法。 该方法包括在羟基源和催化剂体系的存在下使所述化合物与一氧化碳反应。 催化剂体系可以通过以下方法获得：（a）第8,9或10族金属或其化合物：和（b）通式（I）的二齿配体：X1（X2）-Q2-AR-B- Q1-X3（X4）。
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公开(公告)号：US09315446B2
公开(公告)日：2016-04-19
申请号：US13823406
申请日：2011-09-16
Applicant: Joseph P. St. Laurent , Scott A. Goodrich , Gerald S. Jones, Jr.
Inventor： Joseph P. St. Laurent , Scott A. Goodrich , Gerald S. Jones, Jr.
IPC: C07C69/68 , C12P7/62 , C08G65/332
CPC classification number: C07C69/68 , C07B2200/07 , C08G65/3322 , C12P7/62 , C12Y301/01003 , Y02P20/52
Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
Abstract translation: 本文描述的是组合物（例如，药物组合物）和式I化合物，制备式（I）化合物的方法及其在治疗和/或预防疾病和病症中的用途。
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