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    BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS
    1.
    发明申请
    BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS 审中-公开
    端基烯丙基C-H的碱催化苯乙烯

    公开(公告)号：US20160347776A1

    公开(公告)日：2016-12-01

    申请号：US15166405

    申请日：2016-05-27

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： ANTON TOUTOV ,  WENBO LIU ,  KERRY BETZ ,  ALEXEY FEDOROV ,  BRIAN M. STOLTZ ,  ROBERT H. GRUBBS

    IPC分类号： C07F7/08 ,  C08F30/08

    CPC分类号： C07F7/0829

    摘要： The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic C—H bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. The systems associated with these methods are also disclosed.

    摘要翻译： 本发明涉及末端烯烃的温和，有效和通用的直接C（sp 2）-H键甲硅烷基化。 各种实施方案包括方法，每种方法包括或基本上使至少一种包含末端烯烃C-H键的有机底物与至少一种有机硅烷，有机硅烷或其混合物的混合物和碱金属醇盐或碱金属氢氧化物 ，使得接触导致形成甲硅烷基化的烯烃产物。 还公开了与这些方法相关联的系统。

    SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS
    3.
    发明申请
    SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS 有权
    通过接地过渡金属催化剂对芳香杂环化合物进行硅烷化

    公开(公告)号：US20160046653A1

    公开(公告)日：2016-02-18

    申请号：US14818417

    申请日：2015-08-05

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： ANTON TOUTOV ,  KERRY BETZ ,  ALEXEY FEDEROV ,  BRIAN M. STOLTZ ,  WENBO LIU ,  ROBERT H. GRUBBS

    IPC分类号： C07F7/08 ,  C07D209/12 ,  C08G75/06 ,  C07B51/00

    CPC分类号： C07F7/0801 ,  C07D209/12 ,  C07F7/0827 ,  C07F7/0832

    摘要： The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.

    摘要翻译： 本发明描述了用于甲硅烷基化芳族有机基质的化学体系和方法，所述体系或方法包括或主要由（a）至少一种有机硅烷和（b）至少一种强碱的混合物组成，或者基本上由 包括氢氧化物，特别是KOH，所述体系优选但不一定基本上不含过渡金属化合物，并且所述方法包括使一定量的有机底物与（a）至少一种有机硅烷和（b）的混合物接触 至少一个强碱，在足以甲酰化芳族底物的条件下; 其中所述体系基本上不含过渡金属化合物。

    BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS
    5.
    发明申请
    BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS 有权
    端基烷基C-H键的碱催化苯乙烯

    公开(公告)号：US20160060278A1

    公开(公告)日：2016-03-03

    申请号：US14841964

    申请日：2015-09-01

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： ANTON TOUTOV ,  KERRY BETZ ,  BRIAN M. STOLTZ ,  WENBO LIU ,  ROBERT H. GRUBBS

    IPC分类号： C07F7/08 ,  C07F17/02 ,  C07J7/00

    CPC分类号： C07F7/0827 ,  C07F17/02 ,  C07J1/0096 ,  C07J7/0005 ,  C07J51/00 ,  C07J75/00

    摘要： The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.

    摘要翻译： 本发明涉及温和，有效和通用的直接C（sp）-H键甲硅烷基化。 各种实施方案包括方法，每种方法包括或基本上包括使至少一种包含末端炔基C-H键的有机底物与至少一种有机硅烷和碱金属氢氧化物的混合物在足以形成甲硅烷基化的末端炔基的条件下 部分。 所述方法在基本上不存在过渡金属化合物的情况下是可操作的。 还公开了与这些方法相关联的系统。

    SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS
    8.
    发明申请
    SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS 有权
    使用磷酸烷氧化物催化剂进行游离的芳烃杂环化合物

    公开(公告)号：US20160176772A1

    公开(公告)日：2016-06-23

    申请号：US14972653

    申请日：2015-12-17

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： ANTON TOUTOV ,  WENBO LIU ,  BRIAN M. STOLTZ ,  ROBERT H. GRUBBS ,  KERRY BETZ ,  DAVID P. SCHUMAN

    IPC分类号： C07B47/00 ,  C07D209/12 ,  B01J31/22 ,  C07F7/08

    CPC分类号： C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

    摘要： The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.

    摘要翻译： 本发明描述了用于甲硅烷基化杂芳族有机底物的化学系统和方法，所述系统基本上由（a）至少一种有机硅烷和（b）至少烷氧基，优选烷醇钾碱的混合物组成，所述方法包括使 基本上由（a）至少一种有机硅烷和（b）至少一种醇盐碱，优选烷氧基钾，在足以使所述杂芳族底物甲硅烷基化的条件下混合的混合物的有机底物的量。