公开(公告)号：US20180170911A1

公开(公告)日：2018-06-21

申请号：US15512661

申请日：2015-09-18

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Tristan REUILLON ,  Duncan MILLER ,  Stephanie MYERS ,  Lauren MOLYNEUX ,  Celine CANO ,  Ian HARDCASTLE ,  Roger GRIFFIN ,  Laurent RIGOREAU ,  Bernard GOLDING ,  Martin NOBLE

IPC: C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D413/12 ,  C07D405/14 ,  C07D401/12 ,  C07D403/14 ,  A61P35/00

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.