专利检索 ap:("CANSINO BIOLOGICS INC.") AND inv:"Juan SHAO" 第 1 页

1.

发明公开
CARRIER PROTEIN SUBJECTED TO SITE-DIRECTED MUTATION AND USE THEREOF IN PREPARATION OF VACCINE 审中-公开

公开(公告)号：US20230183298A1

公开(公告)日：2023-06-15

申请号：US18150496

申请日：2023-01-05

申请人： CANSINO BIOLOGICS INC.

发明人： Haomeng WANG , Zhihong YAN , Qiaoling YAN , Juan SHAO , Jianming SHI , Xiuwen SUI , Junqiang LI , Tao ZHU

IPC分类号： C07K14/22 , A61K39/116

CPC分类号： C07K14/22 , A61K39/116

摘要： Provided are a protein antigen subjected to site-directed mutation and site-directed modification, and a method for site-directed mutation and site-directed modification of the protein antigen. The method comprises: site-directedly introducing an unnatural amino acid into a specific site of the protein antigen by genetic codon expansion technique; and performing site-directed modification with the protein antigen by the unnatural amino acid and a modifier, wherein the modifier is a receptor agonist such as tripalmitoyl-S-glyceryl cysteine and monophosphoryl lipid A. Further provided is use of the protein antigen subjected to site-directed mutation and site-directed modification, such as use as a vaccine.