公开(公告)号：US20240132550A1

公开(公告)日：2024-04-25

申请号：US18328162

申请日：2023-06-01

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Maria SCARSELLI ,  Daniele VEGGI

IPC分类号： C07K14/22 ,  A61K39/095 ,  A61P31/04

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61P31/04 ,  C07K2319/00

摘要： The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.

公开(公告)号：US20240101610A1

公开(公告)日：2024-03-28

申请号：US18493141

申请日：2023-10-24

申请人： Children’s Hospital & Research Center at Oakland

发明人： Peter T. BEERNINK

IPC分类号： C07K14/22 ,  A61K39/095

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61K2039/55505

摘要： Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.

公开(公告)号：US20240025951A1

公开(公告)日：2024-01-25

申请号：US18316594

申请日：2023-05-12

申请人： Children’s Hospital & Research Center at Oakland

发明人： Peter T. Beernink

IPC分类号： C07K14/22 ,  A61K39/095

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61K2039/55505

摘要： Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.

公开(公告)号：US20230414736A1

公开(公告)日：2023-12-28

申请号：US18329701

申请日：2023-06-06

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Alessia BIOLCHI ,  Brunella BRUNELLI ,  Marzia GIULIANI ,  Vega MASIGNANI

IPC分类号： A61K39/095 ,  C07K14/22 ,  A61K39/385

CPC分类号： A61K39/095 ,  C07K14/22 ,  A61K39/385 ,  A61K2039/55505

摘要： Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.

公开(公告)号：US11801293B2

公开(公告)日：2023-10-31

申请号：US17085924

申请日：2020-10-30

申请人： Children's Hospital & Research Center at Oakland

发明人： Dan M. Granoff ,  Victor Chen-Hsi Hou

IPC分类号： A61K39/095 ,  C07K14/22 ,  A61K39/00 ,  A61K9/127

CPC分类号： A61K39/095 ,  A61K9/127 ,  C07K14/22 ,  A61K2039/522 ,  A61K2039/575 ,  Y10S530/825

摘要： The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.

公开(公告)号：US11730800B2

公开(公告)日：2023-08-22

申请号：US17024618

申请日：2020-09-17

申请人： PFIZER INC.

发明人： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC分类号： A61K39/095 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00 ,  A61K47/18 ,  A61K47/10 ,  A61K47/26 ,  A61K31/7028 ,  A61P31/00 ,  A61K39/12

CPC分类号： A61K39/095 ,  A61K31/7028 ,  A61K39/12 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  A61K47/646 ,  A61K47/6415 ,  A61P31/00 ,  C07K14/22 ,  C07K16/1217 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N2770/32434

摘要： In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US11707513B2

公开(公告)日：2023-07-25

申请号：US15319665

申请日：2015-07-16

申请人： GLAXOSMITHKLINE BIOLOGICALS, SA

发明人： Alessia Biolchi ,  Brunella Brunelli ,  Marzia Monica Giuliani ,  Vega Masignani

IPC分类号： A61K39/095 ,  C07K14/22 ,  A61K39/00 ,  A61K39/385

CPC分类号： A61K39/095 ,  A61K39/385 ,  C07K14/22 ,  A61K39/00 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K2319/00

摘要： Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.

公开(公告)号：US11680087B2

公开(公告)日：2023-06-20

申请号：US17126712

申请日：2020-12-18

申请人： Pfizer Inc.

发明人： Annaliesa Sybil Anderson ,  Rasappa Gounder Arumugham ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Kathrin Ute Jansen ,  Thomas Richard Jones ,  Lakshmi Khandke ,  Bounthon Loun ,  John Lance Perez ,  Gary Warren Zlotnick

IPC分类号： A61K39/05 ,  C07K14/22 ,  A61K39/00 ,  A61K39/13 ,  A61K39/295 ,  A61K39/095 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00

CPC分类号： C07K14/22 ,  A61K39/0016 ,  A61K39/095 ,  A61K39/12 ,  A61K39/13 ,  A61K39/295 ,  A61K39/39 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/70 ,  C12N2710/20034 ,  C12N2770/32634 ,  Y02A50/30

摘要： In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.

公开(公告)号：US20190183999A1

公开(公告)日：2019-06-20

申请号：US16219494

申请日：2018-12-13

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Davide Serruto ,  Mariagrazia Pizza ,  Isabel Delany

IPC分类号： A61K39/095 ,  C12N1/20 ,  C07K14/22 ,  C12N9/10 ,  C12N1/38

CPC分类号： A61K39/095 ,  A61K2039/523 ,  C07K14/22 ,  C12N1/20 ,  C12N1/38 ,  C12N9/1085 ,  C12Y205/01072

摘要： A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant antigen of interest.

公开(公告)号：US10072049B2

公开(公告)日：2018-09-11

申请号：US15095808

申请日：2016-04-11

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/095 ,  C07K14/22 ,  A61K47/64 ,  A61K38/00

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K47/64

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.