公开(公告)号：US10143650B2

公开(公告)日：2018-12-04

申请号：US14383186

申请日：2013-03-08

Applicant: CAPSUM

Inventor： Jérôme Bibette ,  Thomas Delmas ,  Enric Santanach Carreras ,  Leslie Rolland

IPC: A23P10/30 ,  A61K9/10 ,  A61K8/04 ,  A61Q9/00 ,  A61K8/11 ,  A61Q19/00

Abstract: A dispersion including a plurality of bodies dispersed in a continuous phase. Each dispersed body including an internal drop formed with an internal phase miscible with the continuous phase, the internal drop (16) receiving an active product. Each dispersed body including, around the internal drop, a membrane formed with an intermediate phase immiscible with the continuous phase and totally surrounding the internal drop. The ratio R1 of the average thickness (e) of the membrane over the average transverse dimension (Dc) of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5. The ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s−1·Pa−1.

公开(公告)号：US20150030648A1

公开(公告)日：2015-01-29

申请号：US14383186

申请日：2013-03-08

Applicant: CAPSUM

Inventor： Jérôme Bibette ,  Thomas Delmas ,  Enric Santanach Carreras ,  Leslie Rolland

IPC: A23L1/00 ,  A61K8/11 ,  A61K9/10 ,  A61K8/04

CPC classification number: A61K9/10 ,  A23P10/30 ,  A23V2002/00 ,  A61K8/04 ,  A61K8/11 ,  A61K2800/10 ,  A61K2800/56 ,  A61K2800/63 ,  A61Q19/00

Abstract: A dispersion including a plurality of bodies dispersed in a continuous phase. Each dispersed body including an internal drop formed with an internal phase miscible with the continuous phase, the internal drop (16) receiving an active product. Each dispersed body including, around the internal drop, a membrane formed with an intermediate phase immiscible with the continuous phase and totally surrounding the internal drop. The ratio R1 of the average thickness (e) of the membrane over the average transverse dimension (Dc) of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5. The ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s−1·Pa−1.

Abstract translation: 包含分散在连续相中的多个主体的分散体。 每个分散体包括形成有与连续相混合的内部相的内部液滴，内部液滴（16）接收活性产物。 每个分散体包括在内部液滴周围的膜，其形成有与所述连续相不混溶并完全围绕内部液滴的中间相。 膜的平均厚度（e）与由内滴和膜界定的活性体积的平均横向尺寸（Dc）的比值R1大于0.05，有利地小于0.5。 形成膜的中间相和形成内膜的内部相的活性产物在膜的粘度上的分配系数的比值R2小于1s-1·Pa-1。