公开(公告)号：US20160132637A1

公开(公告)日：2016-05-12

申请号：US14939363

申请日：2015-11-12

Applicant: Case Western Reserve University

Inventor： Vinay Varadan ,  Kishore Guda

IPC: G06F19/22 ,  G06F19/24

CPC classification number: G16B30/00 ,  G16B20/00 ,  G16B40/00

Abstract: This disclosure relates to systems and methods that employ a noise model generated from control samples to detect copy number alterations (CNA) in one or more test samples. The noise model can be generated to represent an indication of noise associated with chromosomes of control biological samples obtained via a common protocol. The indication can be determined by comparing chromosomes of the control biological samples. The noise model can be used to detect CNAs within the test sample by analyzing variability thereof with respect to the noise model.

Abstract translation: 本公开涉及使用由控制样本产生的噪声模型来检测一个或多个测试样本中的拷贝数变更（CNA）的系统和方法。 可以产生噪声模型以表示通过通用协议获得的对照生物样品的染色体相关噪声的指示。 可以通过比较对照生物样品的染色体来确定适应症。 噪声模型可用于通过分析与噪声模型相关的变异性来检测测试样本中的CNA。

公开(公告)号：US20180327849A1

公开(公告)日：2018-11-15

申请号：US15568334

申请日：2016-04-20

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Kishore Guda ,  Amitabh Chak ,  Anne-Marie Kieber-Emmons

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12N15/111 ,  C12N15/113 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: A method of analyzing tissue in a subject having or suspected of having cancer includes obtaining an expression profile from a sample of tissue obtained from the subject, wherein the expression profile comprises the level of at least one esophageal adenocarcinoma associated lincRNA selected from the group consisting of linc-PRKD, lincRTL, lincMIA, lincNAV, and lincTMEM.

公开(公告)号：US10465251B2

公开(公告)日：2019-11-05

申请号：US15568334

申请日：2016-04-20

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Kishore Guda ,  Amitabh Chak ,  AnnMarie Kieber-Emmons

IPC: C12Q1/6886 ,  C12N15/11 ,  C12N15/113

Abstract: A method of analyzing tissue in a subject having or suspected of having cancer includes obtaining an expression profile from a sample of tissue obtained from the subject, wherein the expression profile comprises the level of at least one esophageal adenocarcinoma associated lincRNA selected from the group consisting of linc-PRKD, lincRTL, lincMIA, lincNAV, and lincTMEM.