公开(公告)号：US20240041847A1

公开(公告)日：2024-02-08

申请号：US18461023

申请日：2023-09-05

申请人： CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Krzysztof Palczewski ,  Yuanyuan Chen

IPC分类号： A61K31/4402 ,  A61P29/00 ,  A61K31/365 ,  A61K31/381

CPC分类号： A61K31/4402 ,  A61P29/00 ,  A61K31/365 ,  A61K31/381

摘要： A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US20200230119A1

公开(公告)日：2020-07-23

申请号：US16609162

申请日：2018-04-30

申请人： CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF PITTSBURGH

发明人： Krzysztof Palczewski ,  Yuanyuan Chen

IPC分类号： A61K31/4402 ,  A61K31/365 ,  A61K31/381 ,  A61P29/00

摘要： This application relates to compounds and methods of treating retinal degeneration associated with inherited rhodopsin mutations in the ocular tissue of a subject. The retinal degeneration, can include, for example, macular degeneration, a including age-related macular degeneration, Stargardt disease, and retinitis pigmentosa. The retinitis pigmentosa can include autosomal dominate retinitis pigmentosa associated with a P23H RHO mutation. A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I), wherein the compound of formula (I) acts as a chaperone of rhodopsin.

公开(公告)号：US11191752B2

公开(公告)日：2021-12-07

申请号：US16609162

申请日：2018-04-30

申请人： CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF PITTSBURGH

发明人： Krzysztof Palczewski ,  Yuanyuan Chen

IPC分类号： A61K31/4402 ,  A61P29/00 ,  A61K31/365 ,  A61K31/381

摘要： This application relates to compounds and methods of treating retinal degeneration associated with inherited rhodopsin mutations in the ocular tissue of a subject. The retinal degeneration, can include, for example, macular degeneration, a including age-related macular degeneration, Stargardt disease, and retinitis pigmentosa. The retinitis pigmentosa can include autosomal dominate retinitis pigmentosa associated with a P23H RHO mutation. A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I), wherein the compound of formula (I) acts as a chaperone of rhodopsin.

公开(公告)号：US11744826B2

公开(公告)日：2023-09-05

申请号：US17544454

申请日：2021-12-07

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Krzysztof Palczewski ,  Yuanyuan Chen

IPC分类号： A61K31/4402 ,  A61P29/00 ,  A61K31/365 ,  A61K31/381

CPC分类号： A61K31/4402 ,  A61K31/365 ,  A61K31/381 ,  A61P29/00

摘要： A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US20220087992A1

公开(公告)日：2022-03-24

申请号：US17544454

申请日：2021-12-07

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Krzysztof Palczewski ,  Yuanyuan Chen

IPC分类号： A61K31/4402 ,  A61P29/00 ,  A61K31/365 ,  A61K31/381

摘要： A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US20230089949A1

公开(公告)日：2023-03-23

申请号：US17799546

申请日：2021-04-19

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Lori Birder ,  Edwin Kerry Jackson ,  Amanda Wolf-Johnston ,  José-Alain Sahel ,  Yuanyuan Chen

IPC分类号： A61K31/522 ,  A61P27/02

摘要： Disclosed herein are methods of treating age-related retinal diseases by administering to the subject a therapeutically effective amount of a purine nucleoside phosphorylase (PNPase) inhibitor and/or a PNPase purine nucleoside substrate. In some examples, the subject can have AMD or glaucoma.