公开(公告)号：US20160017013A1

公开(公告)日：2016-01-21

申请号：US14761157

申请日：2013-08-20

Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： In-Sook KIM ,  Mi-Kyung OH

IPC: C07K14/47

CPC classification number: C07K14/4717 ,  A61K38/00 ,  C07K14/47

Abstract: The present invention relates to a use of mutant haptoglobin having angiogenesis-promoting activity and, more particularly, to a mutant haptoglobin polypeptide, a recombinant vector containing a polynucleotide encoding the polypeptide, or a composition for promoting angiogenesis containing, as an active ingredient, a transformant transformed with the recombinant vector. The mutant haptoglobin according to the present invention includes an amino acid sequence of SEQ ID NO: 1 in which the 143rd amino acid is substituted with an amino acid other than Arg. The mutant haptoglobin according to the present invention has excellent angiogenesis-promoting activity and excellent capillary-like tube formation capability as compared with wild-type haptoglobin, and promotes cell migration, and thus is useful as a therapeutic agent for treating diseases caused by non-angiogenesis.

Abstract translation: 本发明涉及具有血管生成促进活性的突变型触珠蛋白的用途，更具体地说，涉及突变型触珠蛋白多肽，含有编码该多肽的多核苷酸的重组载体，或用于促进血管生成的组合物，其含有作为活性成分的 转化体用重组载体转化。 根据本发明的突变型触珠蛋白包含SEQ ID NO：1的氨基酸序列，其中第143位氨基酸被除Arg以外的氨基酸取代。 与野生型触珠蛋白相比，本发明的突变型触珠蛋白具有优异的血管生成促进活性和优异的毛细管样管形成能力，促进细胞迁移，因此可用作治疗由非 - 血管生成。