专利检索 ap:("CEDARS-SINAI MEDICAL CENTER") AND inv:"Noriko Ammerman" 第 1 页

1.

发明公开
INTRA-RENAL INFUSIONS OF C1 INHIBITOR PRIOR TO TRANSPLANTATION OF ALLOGRAFTS TO REDUCE DELAYED GRAFT FUNCTION AND ISCHEMIA/REPERFUSION INJURY AND TO IMPROVE LONG-TERM GRAFT FUNCTION 审中-公开

公开(公告)号：US20240050541A1

公开(公告)日：2024-02-15

申请号：US18267408

申请日：2021-12-21

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Stanley C. Jordan , Noriko Ammerman , Ashley Vo , Irene Kim , Sanjeev Kumar

IPC分类号： A61K38/57 , A61K31/5377 , A61K31/522 , A61K31/43 , A61K31/573 , A61P37/06

CPC分类号： A61K38/57 , A61K31/5377 , A61K31/522 , A61K31/43 , A61K31/573 , A61P37/06

摘要： The present invention describes method for reducing Delayed Graft Function (DGF) and Ischemia/Reperfusion Injury (IRI) by intra-renal infusion of a C1 esterase inhibitor.

2.

发明申请
Use of Calcineurin Inhibitor Free CTLA4-IG + Anti-IL6/IL6R For Long Term Immunosuppression in Solid Organ Transplant Recipients 有权

公开(公告)号：US20220288202A1

公开(公告)日：2022-09-15

申请号：US17639654

申请日：2020-09-04

申请人： Cedars-Sinai Medical Center

发明人： Stanley C. Jordan , Ashley Vo , Noriko Ammerman , Edmund Huang , Irene Kim

IPC分类号： A61K39/395 , A61P37/06 , A61K38/17 , A61K38/13 , A61K31/436

摘要： The present invention provides for methods and uses of (i) an IL-6 inhibitor or IL-6R inhibitor, or both; and (ii) CT-LA-4 or CTLA-4 fusion proteins for immunosuppression and/or immunomodulation in a solid organ transplant recipient. Various embodiments of the method comprise administering an IL-6 inhibitor or IL-6R inhibitor, or both to the recipient; and administering a or CTLA-4 fusion protein such as CTLA4-Ig to the recipient and may further include administration or use of a calcineurin inhibitor.