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公开(公告)号：US10982189B2
公开(公告)日：2021-04-20
申请号：US15325376
申请日：2015-07-10
申请人： CELGENE CORPORATION
发明人： Bitao Liang , Wei Liu
IPC分类号： C12N5/0783 , C12N7/00 , C12N15/86 , C12N15/87
摘要： Provided herein are methods for enhancing the transduction efficiency of vectors into cells, e.g., primary human T lymphocytes.
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公开(公告)号：US11834675B2
公开(公告)日：2023-12-05
申请号：US16067536
申请日：2016-12-29
申请人： CELGENE CORPORATION
发明人： Bitao Liang , Xiaohua Lu , Wei Liu , Kathy E. Karasciewicz-Mendez , Christopher Wiwi , Kruti Shah
IPC分类号： C12N5/0783 , A61K39/00 , A61K35/17 , C07K16/28
CPC分类号： C12N5/0636 , A61K35/17 , A61K39/0011 , C07K16/2818 , C07K16/2827 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315
摘要： Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.
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公开(公告)号：US11629335B2
公开(公告)日：2023-04-18
申请号：US17200745
申请日：2021-03-12
申请人： CELGENE CORPORATION
发明人： Bitao Liang , Wei Liu
IPC分类号： C12N7/00 , A61K39/00 , C12N5/0783 , C12N15/86 , C12N15/87
摘要： Provided herein are methods for enhancing the transduction efficiency of vectors into cells, e.g., primary human T lymphocytes.
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公开(公告)号：US20180273640A1
公开(公告)日：2018-09-27
申请号：US15990561
申请日：2018-05-25
申请人： Celgene Corporation
发明人： Bitao Liang , Stewart Abbot , Wei Liu
IPC分类号： C07K16/40 , C12N5/0783 , C07K14/725 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： C07K16/40 , A61K39/0011 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70521 , C07K14/71 , C07K16/2863 , C07K16/32 , C07K2317/622 , C07K2317/76 , C07K2319/03 , C07K2319/33 , C12N5/0636 , C12N5/0638 , C12N2510/00
摘要： Provided herein are modified T lymphocytes comprising chimeric receptors and methods of use thereof.
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