公开(公告)号：US10065912B2

公开(公告)日：2018-09-04

申请号：US15473940

申请日：2017-03-30

Applicant: CENTRAL GLASS COMPANY, LIMITED

Inventor： Takaaki Yoshimura ,  Toshihiko Oono ,  Shinya Akiba ,  Masaki Fujiwara

IPC: C07C43/00 ,  C07C41/42 ,  C07C41/22

CPC classification number: C07C41/42 ,  C07C41/22 ,  C07C41/44 ,  C07C43/123

Abstract: An object of the present invention is to remove a compound A from “sevoflurane containing fluoromethyl-1,1,3,3,3-pentafluoroisopropenyl ether (compound A)” so as to collect high-purity sevoflurane. The present invention concerns a method for producing sevoflurane containing substantially no compound A, comprising the following steps of: bringing a composition containing hydrogen fluoride (HF) and water at a mass ratio of 1:1 to 1:30 into contact with a 1st organic liquid containing sevoflurane and a compound A, thereby obtaining a 2nd organic liquid containing the compound A in an amount that is lower than that in the 1st organic liquid (step 1a); and distilling the 2nd organic liquid under the presence of a degradation inhibitor, thereby obtaining sevoflurane containing substantially no compound A as a main distillation fraction (step 2).