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    Method for producing sevoflurane
    2.
    发明授权
    Method for producing sevoflurane 有权

    公开(公告)号：US10065912B2

    公开(公告)日：2018-09-04

    申请号：US15473940

    申请日：2017-03-30

    Applicant: CENTRAL GLASS COMPANY, LIMITED

    Inventor： Takaaki Yoshimura ,  Toshihiko Oono ,  Shinya Akiba ,  Masaki Fujiwara

    IPC: C07C43/00 ,  C07C41/42 ,  C07C41/22

    CPC classification number: C07C41/42 ,  C07C41/22 ,  C07C41/44 ,  C07C43/123

    Abstract: An object of the present invention is to remove a compound A from “sevoflurane containing fluoromethyl-1,1,3,3,3-pentafluoroisopropenyl ether (compound A)” so as to collect high-purity sevoflurane. The present invention concerns a method for producing sevoflurane containing substantially no compound A, comprising the following steps of: bringing a composition containing hydrogen fluoride (HF) and water at a mass ratio of 1:1 to 1:30 into contact with a 1st organic liquid containing sevoflurane and a compound A, thereby obtaining a 2nd organic liquid containing the compound A in an amount that is lower than that in the 1st organic liquid (step 1a); and distilling the 2nd organic liquid under the presence of a degradation inhibitor, thereby obtaining sevoflurane containing substantially no compound A as a main distillation fraction (step 2).

    PRODUCTION OF PROPYLENE GLYCOL MONOALKYL ETHER
    4.
    发明申请
    PRODUCTION OF PROPYLENE GLYCOL MONOALKYL ETHER 有权
    丙烯甘油单烷基醚的生产

    公开(公告)号：US20160031779A1

    公开(公告)日：2016-02-04

    申请号：US14880653

    申请日：2015-10-12

    Applicant: Lyondell Chemical Technology, L.P.

    Inventor： XIANGMIN LI ,  Lawrence M. Candela ,  Mark A. Liepa ,  David W. Leyshon

    IPC: C07C41/03

    CPC classification number: C07C41/03 ,  C07C41/42 ,  C07C41/44 ,  C07C43/13

    Abstract: Processes for producing propylene glycol monoalkyl ether are described herein and include contacting propylene oxide and an alcohol in the presence of an alkali or alkaline earth metal alkoxide catalyst to produce an alkoxylation mixture including propylene glycol monoalkyl ether; distilling the alkoxylation mixture to produce a first overhead stream including propylene oxide and the alcohol and a first bottoms stream including propylene glycol monoalkyl ether; distilling the first bottoms stream to produce a second overhead stream including purified propylene glycol monoalkyl ether and a second bottoms stream including heavier byproducts; further distilling the second bottoms stream to form a resulting bottoms stream including caustic and heavier byproducts; introducing an alkali metal borohydride into at least a portion of the resulting bottoms stream to form an alkali metal borohydride containing stream; and introducing the alkali metal borohydride containing stream into one or more distillations upstream of recovery of the second overhead stream.

    Abstract translation: 本文描述了制备丙二醇单烷基醚的方法，包括在碱金属或碱土金属醇盐催化剂的存在下使环氧丙烷与醇接触以产生包括丙二醇单烷基醚的烷氧基化混合物; 蒸馏所述烷氧基化混合物以产生包含环氧丙烷和所述醇的第一塔顶物流和包含丙二醇单烷基醚的第一塔底物流; 蒸馏第一塔底物流以产生包括纯化的丙二醇单烷基醚和包含较重副产物的第二塔底物流的第二塔顶物流; 进一步蒸馏第二塔底物流以形成包含苛性和重副产物的所得底部物流; 将至少一部分所得的塔底物流中的碱金属硼氢化物引入以形成含碱金属硼氢化物的流; 并将含有碱金属硼氢化物的料流引入到第二塔顶馏出物回收上游的一个或多个蒸馏物中。

    Method for recovering di-trimethylolpropane and trimethylolpropane-enriched product streams from the side streams of trimethylolpropane production
    5.
    发明授权
    Method for recovering di-trimethylolpropane and trimethylolpropane-enriched product streams from the side streams of trimethylolpropane production 有权
    从三羟甲基丙烷生产的侧流回收二羟甲基丙烷和三羟甲基丙烷富集产物流的方法

    公开(公告)号：US09045451B2

    公开(公告)日：2015-06-02

    申请号：US14351205

    申请日：2012-10-24

    Applicant: Oxea GmbH

    Inventor： Guido D. Frey ,  Thorsten Kreickmann ,  Heinz Strutz

    IPC: C07C41/42 ,  C07C29/10 ,  C07D319/06 ,  C07C29/80 ,  C07C29/90 ,  C07C41/44

    CPC classification number: C07D319/06 ,  C07C29/10 ,  C07C29/80 ,  C07C29/90 ,  C07C41/42 ,  C07C41/44 ,  C07C31/22 ,  C07C43/132

    Abstract: Process for obtaining ditrimethylolpropane and trimethylolpropane-enriched product streams from the high-boiling fractions and residues which are obtained in the distillative purification of trimethylolpropane, characterized in that these high-boiling fractions and residues are combined and a polar solvent is added to produce a solution and the solution is treated at a temperature of 120 to 280° C. and at a pressure of 2 to 25 MPa with hydrogen in the presence of a solid nickel catalyst and an acidic compound. After catalytic treatment, the solution is subjected to multi-stage distillation including with a thin film evaporator with a column attachment in order to recover ditrimethylolpropane and trimethylolpropane-enriched product streams.

    Abstract translation: 从三沸石馏分和三羟甲基丙烷的蒸馏提纯中获得的高沸点馏分和残余物获得三羟甲基丙烷和三羟甲基丙烷富集产物流的方法，其特征在于将这些高沸点馏分和残余物合并，加入极性溶剂以产生溶液 在固体镍催化剂和酸性化合物的存在下，用氢气在120〜280℃的温度和2〜25MPa的压力下处理溶液。 在催化处理后，将溶液进行多级蒸馏，包括用柱式附件的薄膜蒸发器，以回收二羟甲基丙烷和富含三羟甲基丙烷的产物流。

    NOVEL ALKOXY-ETHERS AND ALKOXYLATES THEREOF
    9.
    发明申请
    NOVEL ALKOXY-ETHERS AND ALKOXYLATES THEREOF 审中-公开
    新的烷氧基和其烷氧基

    公开(公告)号：US20100179354A1

    公开(公告)日：2010-07-15

    申请号：US12596914

    申请日：2008-04-24

    Applicant: Johan A. Thoen ,  Camiel F. Bartelink ,  Clark S. Davis ,  Pierre T. Varineau ,  Timothy Andrew Morley

    Inventor： Johan A. Thoen ,  Camiel F. Bartelink ,  Clark S. Davis ,  Pierre T. Varineau ,  Timothy Andrew Morley

    IPC: C07C41/03 ,  C07C43/13

    CPC classification number: C07C41/03 ,  B01F17/0021 ,  C07C41/16 ,  C07C41/42 ,  C07C41/44 ,  C07C43/135 ,  C11D1/72 ,  C07C43/11

    Abstract: Novel 1,3-dialkyloxy-2-propanol and alkoxylates thereof may be prepared in good yield by a convenient process comprising adding epichlorohydrin to a stoichiometric excess of alcohol, wherein the ratio of alcohol:epichlorohydrin is at least about 3:1, preferably in the presence of a Group 1A metal hydroxide and a phase transfer catalyst. The result shows excellent selectivity of to the 1,3-substitution positions, and the alkyl chain may be saturated or unsaturated and may contain one or more heteroatoms. The alkoxylates may include repeating alkoxy units in the 2-position. The compositions are useful as surfactants, diluents, and the like.

    Abstract translation: 新的1,3-二烷氧基-2-丙醇及其烷氧基化物可以通过方便的方法以良好的收率制备，包括将表氯醇加入到化学计量过量的醇中，其中醇：表氯醇的比例为至少约3:1， 存在1A族金属氢氧化物和相转移催化剂。 结果显示出优异的1,3-取代位置的选择性，并且烷基链可以是饱和或不饱和的，并且可以含有一个或多个杂原子。 烷氧基化物可以包括2-位上的重复烷氧基单元。 该组合物可用作表面活性剂，稀释剂等。

    NOVEL BRANCHED ALKOXYLATES
    10.
    发明申请
    NOVEL BRANCHED ALKOXYLATES 审中-公开
    新型分支烷基酯

    公开(公告)号：US20100168450A1

    公开(公告)日：2010-07-01

    申请号：US12596919

    申请日：2008-04-24

    Applicant: Johan A. Thoen ,  Camiel F. Bartelink ,  Pierre Varineau

    Inventor： Johan A. Thoen ,  Camiel F. Bartelink ,  Pierre Varineau

    IPC: C07D301/00 ,  C07D303/18

    CPC classification number: C07C41/03 ,  C07C41/16 ,  C07C41/42 ,  C07C41/44 ,  C07C43/11 ,  C08G65/24 ,  C08G65/2609 ,  C08G65/2648 ,  C08G65/2654 ,  C08G65/2678 ,  C11D1/72 ,  C11D1/721 ,  C07C43/135

    Abstract: Novel alkylene oxide-extended alkoxylates of a branched 1,3-dialkyl-oxy-2-propanol may be prepared by a convenient process comprising adding epichlorohydrin to a stoichiometric excess of a branched alcohol, wherein the molar ratio of branched alcohol:epichlorohydrin is at least about 3:1, preferably in the presence of a Group 1 A metal hydroxide and a phase transfer catalyst, followed by alkoxylation in the presence of an ionic catalyst. The branched alkyl chain may be saturated or unsaturated and may contain one or more heteroatoms. The repeating alkoxy units from the alkylene oxide are in the 2-position. The compositions are useful as surfactants, diluents, and the like, and may be less expensive than other branched surfactants.

    Abstract translation: 支链1,3-二烷基 - 氧-2-丙醇的新型环氧烷延展的烷氧基化物可以通过方便的方法制备，包括将表氯醇加入到化学计量过量的支链醇中，其中支链醇：表氯醇的摩尔比为 至少约3:1，优选在第1AA族金属氢氧化物和相转移催化剂存在下，然后在离子催化剂存在下进行烷氧基化。 支链烷基链可以是饱和或不饱和的，并且可以含有一个或多个杂原子。 来自环氧烷烃的重复烷氧基单元为2-位。 该组合物可用作表面活性剂，稀释剂等，并且可能比其它支链表面活性剂便宜。

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