公开(公告)号：US20220290242A1

公开(公告)日：2022-09-15

申请号：US17291407

申请日：2019-11-05

申请人： CENTRE HENRI BECQUEREL ,  UNIVERSITE DE ROUEN-NORMANDIE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE)

发明人： Philippe RUMINY ,  Vinciane MARCHAND ,  Ahmad ABDEL SATER ,  Pierre-Julien VIAILLY ,  Marie Delphine LANIC ,  Fabrice JARDIN ,  Marick LAE ,  Mathieu VIENNOT

IPC分类号： C12Q1/6886

摘要： The invention concerns a method for diagnosing a cancer in a subject, comprising a step of RT-MLPA on a biological sample obtained from the subject, in which the RT-MLPA step is carried out using at least one pair of probes comprising at least one probe chosen among the probes with SEQ ID NO: 1 to 13, and/or the probes with SEQ ID NO: 96 to 99, and/or the probes with SEQ ID NO: 866 to 938, and/or the probes with SEQ ID NO: 940 to 1104, and/or SEQ ID NO: 211 to 1312, and/or the probes with SEQ ID NO: 96 to 99, and/or the probes with SEQ ID NO: 1105 to 1107 and/or the probe with SEQ ID NO: 939 and/or the probes with SEQ ID NO: 1108 to 1123, each of the probes being fused, at at least one end, with a priming sequence, and at least one of the probes of the pair comprising a molecular barcode sequence.

公开(公告)号：US20160319362A1

公开(公告)日：2016-11-03

申请号：US14917087

申请日：2014-09-11

申请人： UNIVERSITE DE ROUEN ,  CENTRE HENRI BECQUEREL ,  INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE

发明人： Philippe RUMINY ,  Vinciane MARCHAND ,  Fabrice JARDIN

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： A method for diagnosing a cancer in a subject, notably with the aim of finding fusion transcripts, includes an RT-MLPA step carried out on a biological sample obtained from the subject using the probes SEQ ID NO: 1 to 25, 30, 31 and 113 to 120, and/or with at least the probes SEQ ID NO: 374 to 405, and/or with at least the probes SEQ ID NO: 524 to 559, each of the probes being fused, at one end at least, with a priming sequence.

摘要翻译： 用于诊断受试者中癌症的方法，特别是为了寻找融合转录物，包括使用探针SEQ ID NO：1至25,30,31和从探针获得的生物学样品进行的RT-MLPA步骤 113至120和/或至少具有探针SEQ ID NO：374至405和/或至少探针SEQ ID NO：524至559的探针，每个探针在一端至少与 启动序列。

公开(公告)号：US20220165355A1

公开(公告)日：2022-05-26

申请号：US17598775

申请日：2020-03-27

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM) ,  UNIVERSITÉ DE ROUEN-NORMANDIE ,  CENTRE HENRI BECQUEREL

发明人： Philippe RUMINY ,  Vinciane MARCHAND ,  Victor BOBÉE ,  Fabrice JARDIN

IPC分类号： G16B25/10 ,  C12N15/10 ,  C12Q1/6886 ,  G16B40/20

摘要： An accurate gene expression based classifier, and the associated assay, which can participate to the establishment a lymphoma diagnosis and to the evaluation of individual prognosis markers are provided. Through its use, one may distinguish subtypes of lymphomas such as ABC DLBCL, GCB DLBCL, PMBL, FL, MCL, SLL and MZL from one another.