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公开(公告)号：US10259794B2
公开(公告)日：2019-04-16
申请号：US15537954
申请日：2015-12-23
Applicant: CEPHALON, INC.
Inventor： Shawn P. Allwein , Roger P. Bakale , Dale R. Mowrey , Daniel E. Petrillo , Sander Kluwer
IPC: C07D241/04 , C07D295/135 , C07D403/12 , A61K31/495
Abstract: The present disclosure is directed to improved methods useful for the preparation of, for example, 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide (CEP-37440).
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