公开(公告)号：US3781432A

公开(公告)日：1973-12-25

申请号：US3781432D

申请日：1971-08-23

申请人： CERM CENT EUROP RECH MAUVERNAY

发明人： MAUVERNAY R ,  BUSCH N ,  SIMOND J ,  MOLEYRE J

IPC分类号： C07D295/092 ,  C07D303/22 ,  A61K27/00

CPC分类号： C07D295/088 ,  C07D303/22

摘要： R IS ALKYL WITH 1 TO 5 CARBON ATOMS, ALKENYL, ALKYNYL, PHENYL, A NITRO SUBSTITUTED PHENYL, OR ARYLALKYL, R4 IS PHENYL, METHOXYPHENYL, PYRIDYL, FURYL, ARYLALKYL,OR ARYLALKENYL, A IS MORPHOLYL, N-METHYLPIPERAZINYL, OR N-BENZYLIPERAZINYL.

WHEREIN

R-O-CH2-CH(-CH2-A)-OOC-R1

A METHOD OF TREATING A PATIENT TO PRODUCE CORONODILATION AND TO PROVIDE ANTI-ARHYTHMIC ACTIVITY, COMPRISING ADMINISTERING TO THE PATIENT A THERAPEUTICALLY EFFECTIVE DOSE OF A COMPOUND HAVING THE FORMUAL.

公开(公告)号：US3806505A

公开(公告)日：1974-04-23

申请号：US10252670

申请日：1970-12-29

申请人： CERM CENT EUROP RECH MAUVERNAY

发明人： SIMOND J ,  MOLEYRE J ,  MAUVERNAY R ,  BUSCH N

IPC分类号： C07D295/13 ,  C07D87/42

CPC分类号： C07D295/13

摘要： IN WHICH R IS LOWER ALKYL HAVING UP TO 5 CARBON ATOMS, PHENYL OR METHYLPHENYL, A IS OXIZATION, AND R1 IS NITROPHENYL, NITROXYPHENYL, OR TRIMETHOXYPHENYL; OR ITS PHYSIOLOGICALLY ACCEPTABLE ACID SALTS. THE AMIDES ARE USEFUL FOR TREATING CARDIAC ACID DISTRUBANCES SUCH AS MYOCARIDIAL ANOXIA, CORONARY INSUFFICIENCY, MYOCARDIAL INFARCTION, AND ARRHYTHMIA.

R-O-CH2-CH(-CH2-A)-NH-CO-R1

AN AMINE OF THE FORMULA

公开(公告)号：US3818000A

公开(公告)日：1974-06-18

申请号：US23896972

申请日：1972-03-28

申请人： CERM CENT EUROP RECH MAUVERNAY

发明人： SIMOND J ,  MOLEYRE J ,  MAUVERNAY R ,  BUSCH N

IPC分类号： C07D295/084 ,  C07D87/32

CPC分类号： C07D295/092

摘要： IN WHICH Ar and Ar'', which may be the same or different, are unsubstituted or substituted aryl groups, R is an aliphatic, aryl or arylaliphatic group, and A is a secondary or tertiary amino group, or an acid addition salt thereof. The compound has coronarodilating properties and central nervous system activity.

A 3-alkoxy- or 3-aryloxy-2-(diaryl-hydroxy)-methyl-propylamine of the formula

摘要翻译： 可以相同或不同的式I Ar和Ar'的3-烷氧基 - 或3-芳氧基-2-（二芳基 - 羟基） - 甲基 - 丙胺是未取代或取代的芳基，R是脂族 ，芳基或芳基脂族基团，A是仲或叔氨基或其酸加成盐。 该化合物具有镇静性和中枢神经系统活性。

公开(公告)号：US3712893A

公开(公告)日：1973-01-23

申请号：US3712893D

申请日：1969-11-10

申请人： CERM CENT EUROP RECH MAUVERNAY

发明人： SIMOND J ,  MOLEYRE J ,  MAUVERNAY R ,  BUSCH N

IPC分类号： C07D295/13 ,  C07D51/70

CPC分类号： C07D295/13 ,  Y10S514/849

摘要： A COMPOUND OF THE FORMULA

1-(4-F-PHENYL),4-(R-C(=R)-NH-CH(-CH3)-CH2-CH2-)PIPERAZINE

IN WHICH R IS A PHENYL GROUP SUBSTITUTED IN THE PARA-POSITION BY A HALOGEN ATOM OR FURYL OR PL;YRIDYL OR A PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALT THERETO.