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35 条记录 (耗时 0.011 秒)

    2h-1,4-benzoxazin-3(4h)-ones
    1.
    发明授权
    2h-1,4-benzoxazin-3(4h)-ones 失效
    2H-1,4-苯并恶嗪-3（4H） - 酮

    公开(公告)号：US3862180A

    公开(公告)日：1975-01-21

    申请号：US36566373

    申请日：1973-05-31

    申请人： HOFFMANN LA ROCHE

    发明人： JERNOW JANE LIU ,  ROSEN PERRY

    IPC分类号： C07C205/26 ,  C07D265/36 ,  C07H17/00 ,  C07D87/32

    CPC分类号： C07H17/00 ,  C07C205/26 ,  C07D265/36

    摘要： A process for the preparation of hydroxamic acids and novel 1,4benzoxazin-3-ones prepared by this process are disclosed. The resulting hydroxamic acids, including the novel 1,4-benzoxazin-3ones, exhibit insecticidal activity.

    摘要翻译： 公开了通过该方法制备异羟肟酸和新的1,4-苯并恶嗪-3-酮的方法。 得到的异羟肟酸，包括新的1,4-苯并恶嗪-3-酮显示出杀虫活性。

    For cyclising 1-aryloxy-3 beta-substituted ethylamino-2-propanols
    2.
    发明授权
    For cyclising 1-aryloxy-3 beta-substituted ethylamino-2-propanols 失效
    循环使用1-芳基-3-取代的乙酰氨基-2-丙醇

    公开(公告)号：US3857839A

    公开(公告)日：1974-12-31

    申请号：US29917472

    申请日：1972-10-19

    申请人： ICI LTD

    发明人： LEE S

    IPC分类号： C07D265/30 ,  C07D87/32

    CPC分类号： C07D265/30

    摘要： A process for the manufacture of 2-aryloxymethyl morpholine derivatives, known to possess useful central nervous depressant activity, by the cyclisation of the corresponding 1-aryloxy-3Beta -substituted ethylamino-2-propanol derivative in which the Beta -substituent is a displaceable radical. This process avoids the use of hazardous complex metal hydrides employed in the prior art process.

    摘要翻译： 已知具有有用的中枢神经抑制活性的2-芳氧基甲基吗啉衍生物的制备方法是通过环化相应的1-芳氧基-3-β-取代的乙基氨基-2-丙醇衍生物，其中β-取代基为 可取代基。 该方法避免使用现有技术方法中使用的危险的复合金属氢化物。

    Terpene derivatives
    3.
    发明授权
    Terpene derivatives 失效
    TERPENE DERIVATIVES

    公开(公告)号：US3845048A

    公开(公告)日：1974-10-29

    申请号：US30643472

    申请日：1972-11-14

    申请人： BERRI BALZAC

    发明人： BARONNET R

    IPC分类号： C07D295/088 ,  C07D87/32

    CPC分类号： C07D295/088

    摘要： 1. A COMPOUND OF THE FORMULA

    6,6-DI(H3C-)-NORPINAN-4-YL-CH2-CH2-O-CH2-CH2-N(+)(-R1)

    (-R3)-R2'' X(-)

    IN WHICH X IS SELECTED FROM THE GROUP CONSISTING OF CHLORO AND BROMO, R1 AND R2 TAKEN SEPARATELY ARE ALKYL HAVING 1-2 CARBON ATOMS AND TEKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A MEMBER SELECTED FROM THE GROUP CONSISTING OF MORPHOLINO, PIPERIDINO AND PYRROLIDINO, R3 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF BENZYL, 2-BROMO-4,5-DIMETHOXY-BENZYL AND 2BROMO-4,5 DIETHOXY-BENZYL.

    3-alkoxy-or 3-aryloxy-2-(diaryl-hydroxy)-methyl-propylamines
    5.
    发明授权
    3-alkoxy-or 3-aryloxy-2-(diaryl-hydroxy)-methyl-propylamines 失效
    3-烷基 - 或3-芳基-2-（二元 - 羟基） - 甲基丙烯酸

    公开(公告)号：US3818000A

    公开(公告)日：1974-06-18

    申请号：US23896972

    申请日：1972-03-28

    申请人： CERM CENT EUROP RECH MAUVERNAY

    发明人： SIMOND J ,  MOLEYRE J ,  MAUVERNAY R ,  BUSCH N

    IPC分类号： C07D295/084 ,  C07D87/32

    CPC分类号： C07D295/092

    摘要： IN WHICH Ar and Ar'', which may be the same or different, are unsubstituted or substituted aryl groups, R is an aliphatic, aryl or arylaliphatic group, and A is a secondary or tertiary amino group, or an acid addition salt thereof. The compound has coronarodilating properties and central nervous system activity.

    A 3-alkoxy- or 3-aryloxy-2-(diaryl-hydroxy)-methyl-propylamine of the formula

    摘要翻译： 可以相同或不同的式I Ar和Ar'的3-烷氧基 - 或3-芳氧基-2-（二芳基 - 羟基） - 甲基 - 丙胺是未取代或取代的芳基，R是脂族 ，芳基或芳基脂族基团，A是仲或叔氨基或其酸加成盐。 该化合物具有镇静性和中枢神经系统活性。

    1-(3,5-dialkoxy-phenoxy)-2-(tertiary amino) ethanes
    6.
    发明授权
    1-(3,5-dialkoxy-phenoxy)-2-(tertiary amino) ethanes 失效
    1-（3,5-二羟基 - 苯氧基）-2-（叔胺氨基）乙烷

    公开(公告)号：US3740397A

    公开(公告)日：1973-06-19

    申请号：US3740397D

    申请日：1970-04-27

    申请人： ORSYMONDE SOC

    发明人： LAFON L

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/14 ,  A61K31/33 ,  C07C67/00 ,  C07C213/00 ,  C07C217/20 ,  C07D295/08 ,  C07D87/32

    CPC分类号： C07D295/08 ,  A61K31/135 ,  A61K31/33 ,  Y10S514/929

    摘要： NEW COMPOUNDS OF THE GENERAL FORMULA,

    (3-(R1-O-),5-(R2-O-)PHENYL)-O-R3-N
    WHERE R1 AND R2, WHICH CAN BE THE SAME EACH REPRESENT A LOWER ALKYL RADICAL OF ORDER C1-C2, R3 REPRESENTS A STRAIGHT OR BRANCHED AKYLENE RADICAL, AND

    N
    IS A GROUP SELECTED FROM THE ALIPHATIC AND N-HETEROCYCLIC AMINO GROUPS, THE LATTER AMINO GROUP BEING CAPABLE OF CONTAINING A SECOND HETERO ATOM, AND THEIR ACID ADDITION SALTS. THESE COMPOUNDS ARE OBTAINED BY THE CONDENSATION IN ALCOHOL, IN THE PRESENCE OF SODIUM, OF A 3,5''-DIALKOXY PHENOL ON A CHLOROALKYLAMINE:

    CL-R3-N
    THE COMPOUND OF FORMULA I AND THEIR ADDITION SALTS ARE THERAPEUTICALLY USEFUL.

    2-amino ethyl-2-hydroxy - 6-vinyl tetrahydropyrans tautomers and optical enantiomers thereof
    7.
    发明授权
    2-amino ethyl-2-hydroxy - 6-vinyl tetrahydropyrans tautomers and optical enantiomers thereof 失效
    2-氨基乙基-2-羟基-6-乙烯基四氢吡喃衍生物及其光学活性剂

    公开(公告)号：US3631039A

    公开(公告)日：1971-12-28

    申请号：US3631039D

    申请日：1969-04-21

    申请人： HOFFMANN LA ROCHE

    发明人： ANDREWS DAVID ,  SAUCY GABRIEL

    IPC分类号： C07D309/10 ,  C07D311/94 ,  C07D87/32

    CPC分类号： C07D309/10 ,  C07D311/94

    摘要： MULTI-STEP PROCESSES FOR THE PREPARATION OF TRICYLIC INTERMEDIATES USEFUL IN THE TOTAL SYNTHESIS OF STEROIDS ARE DESCRIBED. A FIRST PROCESS STEP INVOLVES TREATMENT OF A DIHYDROXY, DIVINYL COMPOUND WITH BOTH MANGANESE DIOXIDE AND AN AMINE TO PRODUCE A MANNICH BASE INTERMEDIATE. THE RESULTING MANNICH BASE INTERMEDIATE MAY BE REDUCED CATALYTICALLY AND THEN COUPLED WITH A CYCLIC DIONE TO YIELD A TRICYCLIC KETO DIENE. THIS COMPOUND CAN BE REDUCED TO YIELD A TRICYCLIC HYDROXY COMPOUND USEFUL AS AN INTERMEDIATE IN THE TOTAL SYNTHESIS OF STERODIAL COMPOUNDS HAVING KNOWN VALUABLE PHARMACOLOGICAL PROPERTIES. ALTERNATIVELY, IT IS POSSIBLE TO DIRECTLY COUPLE THE MANNICH BASE WITH THE CYCLIC DIKETO COMPOUND FOLLOWED BY REDUCTION AND CATALYTIC HYDROGENATION TO YIELD THE TRICYCLIC HYDORXY COMPOUND.