公开(公告)号：US20240199624A1

公开(公告)日：2024-06-20

申请号：US18521696

申请日：2023-11-28

Applicant: CHDI Foundation, Inc.

Inventor： Tasir Haque ,  Michel Maillard ,  Gareth Brace ,  George Ballantyne ,  Elizabeth Frush ,  Kim Hirst ,  Katherine Jones ,  Emanuela Gancia ,  Chris Lock ,  Cole Clissold

IPC: C07D487/04 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

CPC classification number: C07D487/04 ,  A61K9/02 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

Abstract: The present disclosure relates generally to small molecule inhibitors of MutSβ protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.