公开(公告)号：US11685734B2

公开(公告)日：2023-06-27

申请号：US17111307

申请日：2020-12-03

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Perla Breccia ,  Amanda J. Van De Poël ,  Grant Wishart ,  Huw D. Vater ,  William R. K. Esmieu ,  Cole Clissold ,  Wesley P. Blackaby

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/505 ,  A61P21/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P27/02

CPC classification number: C07D413/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04

Abstract: Provided are certain ATM kinase inhibitors of Formula I:




Also provided herein are compositions of such compounds, and methods of their use.

公开(公告)号：US12281116B2

公开(公告)日：2025-04-22

申请号：US17988340

申请日：2022-11-16

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Nikolay V. Plotnikov ,  Alan Haughan ,  Andrew Stott ,  Brett Cosgrove ,  Cole Clissold ,  Huw Vater ,  Jonathan Spencer ,  William Esmieu ,  Karine Malagu ,  Mark Chambers

IPC: C07D471/10 ,  A61K45/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20240199624A1

公开(公告)日：2024-06-20

申请号：US18521696

申请日：2023-11-28

Applicant: CHDI Foundation, Inc.

Inventor： Tasir Haque ,  Michel Maillard ,  Gareth Brace ,  George Ballantyne ,  Elizabeth Frush ,  Kim Hirst ,  Katherine Jones ,  Emanuela Gancia ,  Chris Lock ,  Cole Clissold

IPC: C07D487/04 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

CPC classification number: C07D487/04 ,  A61K9/02 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

Abstract: The present disclosure relates generally to small molecule inhibitors of MutSβ protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US20230159531A1

公开(公告)日：2023-05-25

申请号：US17988340

申请日：2022-11-16

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Nikolay V. Plotnikov ,  Alan Haughan ,  Andrew Stott ,  Brett Cosgrove ,  Cole Clissold ,  Huw Vater ,  Jonathan Spencer ,  William Esmieu ,  Karine Malagu ,  Mark Chambers

IPC: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20210188827A1

公开(公告)日：2021-06-24

申请号：US17111307

申请日：2020-12-03

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Perla Breccia ,  Amanda J. Van De Poël ,  Grant Wishart ,  Huw D. Vater ,  William R. K. Esmieu ,  Cole Clissold ,  Wesley P. Blackaby

IPC: C07D413/14 ,  C07D471/08 ,  C07D498/08

Abstract: Provided are certain ATM kinase inhibitors of Formula I: Also provided herein are compositions of such compounds, and methods of their use.