专利检索 ap:("CHEMO RESEARCH, S.L.") AND inv:"José AMATO" 第 1 页

1.

发明申请
PROCESS FOR THE PREPARATION OF THE COMPOUND N-(3,5-DIMETHYLPHENYL)-N'-(2-TRIFLUOROMETHYLPHENYL) GUANIDINE 审中-公开

公开(公告)号：US20180244608A1

公开(公告)日：2018-08-30

申请号：US15751437

申请日：2016-08-10

申请人： CHEMO RESEARCH, S.L.

发明人： José AMATO

IPC分类号： C07C277/02 , C07C277/06

CPC分类号： C07C277/02 , C07B2200/13 , C07C277/06 , C07C277/08 , C07C279/18

摘要： The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N′-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.