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公开(公告)号：US11358950B2
公开(公告)日：2022-06-14
申请号：US16763746
申请日：2018-11-13
发明人： Yingchun Liu , Zhaobing Xu , Lihong Hu , Charles Z. Ding , Xingxun Zhu , Guoping Hu , Jian Li , Shuhui Chen
IPC分类号： C07D403/06 , C07D403/14 , C07D413/14 , C07D471/04 , A61P35/00
摘要： Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer.
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公开(公告)号：US20220177453A1
公开(公告)日：2022-06-09
申请号：US17594737
申请日：2020-05-09
发明人： Yingchun Liu , Zhaobing Xu , Lihong Hu , Charles Z. Ding , Xingxun Zhu , Shuhui Chen
IPC分类号： C07D403/06
摘要： Provided are a crystallization of an SMAC mimic used as an IAP inhibitor and a preparation method thereof; also comprised is the use of said crystallization in the preparation of a drug for treating cancer benefiting from cIAP1 inhibition. The compound of formula (I) has high crystallization stability and low hygroscopicity, and has advantages in terms of physical properties, safety, and metabolic stability, and has high drug value.
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3.发明申请公开(公告)号：US20190194168A1
公开(公告)日：2019-06-27
申请号：US16331915
申请日：2017-09-08
发明人： Charles Z. Ding , Shuhui Chen , Lihong Hu , Zhaobing Xu , Yingchun Liu , Bingjie Ren , Weidong Li , Zongbin Li , Rui Zhao , Xiquan Zhang
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07B2200/13
摘要： A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.
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公开(公告)号：US20210371400A1
公开(公告)日：2021-12-02
申请号：US16763746
申请日：2018-11-13
发明人： Yingchun Liu , Zhaobing Xu , Lihong Hu , Charles Z. Ding , Xingxun Zhu , Guoping Hu , Jian Li , Shuhui Chen
IPC分类号： C07D403/06 , A61P35/00 , C07D471/04 , C07D403/14 , C07D413/14
摘要： Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer.
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公开(公告)号：US09969719B2
公开(公告)日：2018-05-15
申请号：US15557210
申请日：2016-03-10
发明人： Charles Z. Ding , Shuhui Chen , Baoping Zhao , Zhaobing Xu , Yingchun Liu , Ruibin Lin , Fei Wang , Jian Li
IPC分类号： C07D403/14 , C07D401/14 , C07D471/04 , C07D487/10 , C07D498/04 , C07D487/08
CPC分类号： C07D403/14 , C07D401/14 , C07D471/04 , C07D487/08 , C07D487/10 , C07D498/04
摘要： Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor.
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公开(公告)号：US20180072707A1
公开(公告)日：2018-03-15
申请号：US15557210
申请日：2016-03-10
发明人： Charles Z. Ding , Shuhui Chen , Baoping Zhao , Zhaobing Xu , Yingchun Liu , Ruibin Lin , Fei Wang , Jian Li
IPC分类号： C07D403/14 , C07D401/14 , C07D487/08 , C07D487/10 , C07D498/04 , C07D471/04
CPC分类号： C07D403/14 , C07D401/14 , C07D471/04 , C07D487/08 , C07D487/10 , C07D498/04
摘要： Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor.
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