公开(公告)号：US20160303045A1

公开(公告)日：2016-10-20

申请号：US15196318

申请日：2016-06-29

申请人： CHIESI FARMACEUTICI S.P.A

发明人： Sauro BONELLI ,  Diego Copelli ,  Massimiliano Dagli Alberi ,  Francesca Usberti ,  Enrico Zambelli

IPC分类号： A61K9/12 ,  A61K31/40 ,  A61K31/167 ,  A61M39/22 ,  A61K31/573 ,  A61K31/58 ,  A61M15/00 ,  A61K9/00 ,  A61K45/06

摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof or a solvate of said salt, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in a can internally coated by a resin comprising a fluorinated ethylene propylene (FEP) polymer.

摘要翻译： 用于与加压计量剂量吸入器一起使用的气溶胶溶液组合物，其包含溴化格列溴铵和福莫特罗，或其盐或所述盐的溶剂合物，任选与一种或多种另外的活性成分组合，并通过选定量的矿物质 当包含在由包含氟化乙烯丙烯（FEP）聚合物的树脂内部涂覆的罐中时，表现出改进的稳定性。

公开(公告)号：US20160303044A1

公开(公告)日：2016-10-20

申请号：US15196253

申请日：2016-06-29

申请人： CHIESI FARMACEUTICI S.P.A.

发明人： Sauro BONELLI ,  Diego Copelli ,  Massimiliano Dagli Alberi ,  Francesca Usberti ,  Enrico Zambelli

IPC分类号： A61K9/12 ,  A61K31/40 ,  A61K31/167 ,  A61M39/22 ,  A61K31/573 ,  A61K31/58 ,  A61M15/00 ,  A61K9/00 ,  A61K45/06

摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in an aerosol can provided with a metering valve having at least a butyl rubber gasket.

摘要翻译： 用于与加压计量剂量吸入器一起使用的气溶胶溶液组合物，其包含格列吡酮溴化物和福莫特罗或其盐，任选地与一种或多种另外的活性成分组合并且通过选定量的无机酸稳定，表现出改进的稳定性 包含在具有至少具有丁基橡胶垫圈的计量阀的气溶胶罐中。

公开(公告)号：US10596149B2

公开(公告)日：2020-03-24

申请号：US15379924

申请日：2016-12-15

申请人： CHIESI FARMACEUTICI S.p.A.

发明人： Sauro Bonelli ,  Diego Copelli ,  Massimiliano Dagli Alberi ,  Francesca Usberti ,  Enrico Zambelli

IPC分类号： A61K31/40 ,  A61K9/12 ,  A61K9/00 ,  A61K31/167 ,  A61K47/10 ,  A61K31/573 ,  A61K47/06 ,  A61M15/00 ,  B65D83/14 ,  A61K47/02 ,  B65D83/54 ,  A61K31/58 ,  A61K45/06 ,  A61M39/22 ,  A61K47/08

摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in an aerosol can provided with a metering valve having at least a butyl rubber gasket.

公开(公告)号：US10596113B2

公开(公告)日：2020-03-24

申请号：US14585533

申请日：2014-12-30

申请人： CHIESI FARMACEUTICI S.p.A.

发明人： Sauro Bonelli ,  Diego Copelli ,  Massimiliano Dagli Alberi ,  Francesca Usberti ,  Enrico Zambelli

IPC分类号： A61K31/40 ,  A61K9/12 ,  A61K9/00 ,  A61K31/167 ,  A61K47/10 ,  A61M15/00 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61M39/22

摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof or a solvate of said salt, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in a can internally coated by a resin comprising a fluorinated ethylene propylene (FEP) polymer.