公开(公告)号：US20230131316A1

公开(公告)日：2023-04-27

申请号：US18089265

申请日：2022-12-27

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  MIN-KUAN HSU ,  JIAN-BANG JHENG

IPC: C07C59/46 ,  C07C51/377 ,  C07D313/00

Abstract: The invention relates to processes for preparing Carboprost or Carboprost Tromethamine, and intermediates prepared from the process, and 5,6-trans isomer free Carboprost or Carboprost Tromethamine prepared therefrom. The invention also relates to a novel crystalline form of Carboprost Tromethamine.

公开(公告)号：US20230097470A1

公开(公告)日：2023-03-30

申请号：US17408864

申请日：2021-08-23

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  MIN-KUAN HSU ,  JIAN-BANG JHENG

IPC: C07C59/46 ,  C07D313/00 ,  C07C51/377

Abstract: The invention relates to processes for preparing Carboprost or Carboprost Tromethamine, and intermediates prepared from the process, and 5,6-trans isomer free Carboprost or Carboprost Tromethamine prepared therefrom. The invention also relates to a novel crystalline form of Carboprost Tromethamine.

公开(公告)号：US20210188757A1

公开(公告)日：2021-06-24

申请号：US16720711

申请日：2019-12-19

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  JIAN-BANG JHENG ,  MING-KUN HSU ,  MIN-KUAN HSU ,  TZYH-MANN WEI

IPC: C07C59/72 ,  C07C51/43

Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.